AbstractVesteris Seamount is a large Quaternary intraplate submarine volcano in the SW Greenland Sea, about 1,000 km NE of Iceland and 300 km NW of the Mohn's spreading ridge, whose mode of formation remains unsolved. We present geochemical data for new samples dredged from the Vesteris edifice, including major, trace elements and Sr‐Nd‐Pb‐Hf isotopes. The isotopic characteristics of the alkaline lavas, covering the basanite/tephrite to benmoreite range, indicate the involvement of depleted and enriched mantle components. The source is dominated by the depleted mantle (85%–90%) and a deep enriched component possibly supplied by the Iceland Plume (IP) (10%–15%). Additional source enrichment was due to recycled crust and sub‐continental lithospheric mantle, as suggested by Hf isotopes (0.283147 ± 0.000005) measured for the first time in Vesteris lavas and by a decoupling in Pb isotopes evidenced by relatively low‐radiogenic ²⁰⁷Pb/²⁰⁴Pb (15.510) and high‐radiogenic ²⁰⁸Pb/²⁰⁴Pb (38.554) with respect to the Northern Hemisphere Reference Line. We interpret the geochemical results using existing knowledge about the regional lithospheric and upper mantle structure. Our findings suggest that a deep (ca. 420–320 km) mantle anomaly, with seismological characteristics of the Iceland mantle plume, extends from East Greenland to the north of Jan Mayen Fracture Zone. The regional lithospheric thinning toward the Greenland Basin enabled the melting events that produced the Vesteris seamount. This lateral NNE‐directed flow lobe of the Iceland plume may have carved and transferred enriched components from the continental lithospheric margin of Greenland north of Scoresby Sund toward the Vesteris source.