ABSTRACT Constraints on the potential properties of superconducting cosmic strings provide an indirect probe of physics beyond the standard model at energies inaccessible to terrestrial particle colliders. In this study, we perform the first joint Bayesian analysis to extract constraints on superconducting cosmic strings from current 21-cm signal measurements while accounting rigorously for the uncertainties in foregrounds and high redshift astrophysics. We include the latest publicly available 21-cm power spectrum upper limits from HERA, 21-cm global signal data from SARAS 3, and the synergistic probe of the unresolved X-ray background in our final analysis. This paper thus constitutes the first attempt to use 21-cm power spectrum data to probe cosmic strings. In contrast to previous works, we find no strong constraints can be placed on superconducting cosmic strings from current 21-cm measurements. This is because of uncertainties in the X-ray emission efficiency of the first galaxies, with X-ray emissivities greater than 3 × 1040 erg s−1 M$_{⊙ }^{-1}$ yr able to mask the presence of cosmic strings in the 21-cm signal. We conclude by discussing the prospects for future constraints from definitive 21-cm signal measurements and argue that the recently proposed soft photon heating should be cause for optimism due to its potential to break degeneracies that would have otherwise made the signatures of cosmic strings difficult to distinguish from those of astrophysical origin.