Dissemin is shutting down on January 1st, 2025

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American Physical Society, Physical Review Letters, 6(112), 2014

DOI: 10.1103/physrevlett.112.068101

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Statistical Mechanics Model for the Dynamics of Collective Epigenetic Histone Modification

This paper is available in a repository.
This paper is available in a repository.

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Abstract

Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes. ; Comment: Published in PRL