OBJECTIVE: To assess knowledge of invasive meningococcal disease (IMD) and concern about the disease in the South Australian Community including adolescents, adults, parents and non-parents. METHODS: This cross-sectional study was conducted by face to face interviews in South Australia in 2012. Participants were scored on their knowledge and concern about IMD. Univariate and multivariate regression analyses were performed with the survey data weighted by age and gender in accordance with 2011 Census data. RESULTS: Of 5200 households randomly selected and stratified by metropolitan or rural location, 3055 participants were interviewed with a response rate of 60.3%. The majority were Australian born (74.2%, n=2267) with 31.8% (n=972) of those interviewed being parents, and 15.9% (n=487) adolescents (15-24 years). Almost a quarter of participants (23.5%, n=717) do not know what meningococcal disease is, with 9.1% (n=278) believing incorrectly that IMD is a viral infection. 36.6% (n=1114) had low overall knowledge of IMD. Adolescents (p