Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(65), 2021
DOI: 10.1128/aac.00402-21
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Escherichia coli GyrA Tower Domain Interacts with QnrB1 Loop B and Plays an Important Role in QnrB1 Protection from Quinolone Inhibition
Journal article published in 2021 by
Chunhui Chen,
Yin Wang,
Hidemasa Nakaminami 
,
Eu Suk Kim,
George A. Jacoby,
David C. Hooper
,
Eu Suk Kim,
George A. Jacoby,
David C. Hooper
This paper is made freely available by the publisher.
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Abstract
The Qnr pentapeptide repeat proteins interact with DNA gyrase and protect it from quinolone inhibition. The two external loops, particularly the larger loop B, of Qnr proteins are essential for quinolone protection of DNA gyrase.