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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Journal article published in 2012 by The_DIAbetes_Genetics_Replication_And_Meta-Analysis_(Diagram)_consortium, Andrew P. Morris, Benjamin F. Voight, Teslovich Tm, Tanya M. Teslovich, Teresa Ferreira, Segrè Av, Andre G. Uitterlinden89, Ayellet V. Segré, Valgerdur Steinthorsdottir, Strawbridge Rj, Rona J. Strawbridge ORCID, Hassan Khan, Harald Grallert, Anubha Mahajan and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two demonstrating sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of further common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signalling and cell cycle regulation, in diabetes pathogenesis.