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Tools
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
,
DIAbet Genetics Replication,
S. Asian Type 2. Diabet Sat2d,
Inga Prokopenko ,
Andre G. Uitterlinden89,
Strawbridge Rj,
Fraser Rm,
Nw William Rayner,
Laura J. Scott
and other authors.
Abstract
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two demonstrating sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of further common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signalling and cell cycle regulation, in diabetes pathogenesis.