Published in
Royal Society of Chemistry, Chemical Science, 32(12), p. 10696-10702, 2021
DOI: 10.1039/d1sc02975d
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Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs
Journal article published in 2021 by
Sarah Hostachy 
,
Tillmann Utesch,
Katy Franke,
Gillian Leigh Dornan ,
David Furkert ,
Berke Türkaydin ,
Volker Haucke,
Han Sun,
Dorothea Fiedler
,
Tillmann Utesch,
Katy Franke,
Gillian Leigh Dornan ,
David Furkert ,
Berke Türkaydin ,
Volker Haucke,
Han Sun,
Dorothea Fiedler
This paper is made freely available by the publisher.
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Abstract
An efficient synthesis of non-hydrolyzable inositol pyrophosphate analogs was developed to subsequently investigate the regulation of insulin-degrading enzyme by these hyperphosphorylated signaling molecules.