Published in
Royal Society of Chemistry, Chemical Science, 36(12), p. 11955-11964, 2021
DOI: 10.1039/d1sc01914g
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Genetic encoding of a highly photostable, long lifetime fluorescent amino acid for imaging in mammalian cells
Journal article published in 2021 by
Chloe M. Jones 
,
D. Miklos Robkis ,
Robert J. Blizzard,
Mika Munari,
Yarra Venkatesh ,
Tiberiu S. Mihaila ,
Alex J. Eddins,
Ryan A. Mehl ,
William N. Zagotta ,
Sharona E. Gordon ,
E. James Petersson
,
D. Miklos Robkis ,
Robert J. Blizzard,
Mika Munari,
Yarra Venkatesh ,
Tiberiu S. Mihaila ,
Alex J. Eddins,
Ryan A. Mehl ,
William N. Zagotta ,
Sharona E. Gordon ,
E. James Petersson
This paper is made freely available by the publisher.
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Abstract
Acridonylalanine (Acd) is photostable, with a high quantum yield and long fluorescence lifetime in water. An evolved tRNA synthetase (RS) enables genetic incorporation of Acd in mammalian cells and its use in fluorescence lifetime imaging microscopy.