The performance of precast concrete frame structures against seismic loads mainly depends on the beam-to-column connection. A ductile hybrid connection consists of unbonded post-tensioning steel and bonded reinforcement bars, both of which provide overall moment resistance to the frame. Post-tensioning steel acts as a restoring force which brings the structure back to its initial position upon unloading. Mild steel acts as an energy dissipator which yields in tension and compression. To evaluate the performance of precast frame structures, the structural engineer requires extensive knowledge of the complex nonlinear behavior of the connection. Standardization to mass produce is one of the benefits of precast construction, but with standardization in design there is severe risk. All previous earthquakes have clearly shown that continuous repetition of accepted practice without proper engineering review can lead to disaster. It is important to understand how different parameters of the connection influence the behavior and performance of the frame against seismic loads. The present study helps structural engineers and researchers with a detailed review of hybrid post-tensioned connections. This review is focused mainly on precast beam-to-column connections, studies on the development of hybrid connections, performance evaluations of hybrid connections, and the performance evaluation of precast frames with hybrid connections.