Published in
American Society for Microbiology, Microbiology Spectrum, 2(9), 2021
DOI: 10.1128/spectrum.00481-21
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Reproducibility of the Ribosomal RNA Synthesis Ratio in Sputum and Association with Markers of Mycobacterium tuberculosis Burden
Journal article published in 2021 by
Emmanuel Musisi 
,
Christian Dide-Agossou ,
Reem Al Mubarak,
Karen Rossmassler,
Abdul Wahab Ssesolo,
Sylvia Kaswabuli,
Patrick Byanyima,
Ingvar Sanyu,
Josephine Zawedde,
William Worodria,
Martin I. Voskuil,
Rada M. Savic ,
Payam Nahid,
J. Lucian Davis ,
Laurence Huang
and other authors.
,
Christian Dide-Agossou ,
Reem Al Mubarak,
Karen Rossmassler,
Abdul Wahab Ssesolo,
Sylvia Kaswabuli,
Patrick Byanyima,
Ingvar Sanyu,
Josephine Zawedde,
William Worodria,
Martin I. Voskuil,
Rada M. Savic ,
Payam Nahid,
J. Lucian Davis ,
Laurence Huang
and other authors.
This paper is made freely available by the publisher.
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Abstract
This study takes a major next step toward practical application of a novel pharmacodynamic marker that we believe will have transformative implications for tuberculosis. This article follows our recent report in Nature Communications that an assay called the rRNA synthesis (RS) ratio indicates the treatment-shortening of drugs and regimens.