Drop deformation in fluid flows is investigated as an exchange between the kinetic energy of the fluid and the surface energy of the drop. We show analytically that this energetic exchange is controlled only by the stretching (or compression) of the drop surface by the rate-of-strain tensor. This mechanism is analogous to the stretching of the vorticity field in turbulence. By leveraging the non-local nature of turbulence dynamics, we introduce a new decomposition that isolates the energetic exchange arising from local drop-induced surface effects from the non-local action of turbulent fluctuations. We perform direct numerical simulations of single inertial drops in isotropic turbulence and show that an important contribution to the increments of the surface energy arises from the non-local stretching of the fluid–fluid interface by eddies far from the drop surface (outer eddies). We report that this mechanism is dominant and independent of surface dynamics in a range of Weber numbers in which drop breakup occurs. These findings shed new light on drop deformation and breakup in turbulent flows, and opens the possibility for the improvement and simplification of breakup models.