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Public Library of Science, PLoS Genetics, 7(8), p. e1002829, 2012

DOI: 10.1371/journal.pgen.1002829

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GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program

Journal article published in 2012 by Amelia Soto Hopkin, William Gordon, Rachel Herndon Klein, Francisco Espitia, Kenneth Daily ORCID, Michael Zeller, Pierre Baldi, Bogi Andersen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes.