In this article we aim to provide perspectives on learning strategies that have been activated for the effective training and development of entrepreneurial skills and the sense of initiative among students in the educational process of biology and chemistry through a transdisciplinary perspective. We as well put forward in the paper elements of originality from two perspectives: we suggest a set of characteristics of entrepreneurial competence and the sense of initiative among students and we argue that the formation and development of entrepreneurial competence and the sense of initiative is an evolutionary process that combines the dynamic exploitation of knowledge transdisciplinary learning.