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BioMed Central, Gut Pathogens, 1(1), 2009

DOI: 10.1186/1757-4749-1-23

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Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

Journal article published in 2009 by Sébastien Van de Velde ORCID, Stéphane Carryn, Françoise Van Bambeke, Colin Hill, Paul M. Tulkens, Roy D. Sleator
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem. ; Direction Générale de la Recherche et des Technologies of the Région Wallonne, Belguim (FIRST-Doctorate Fellowship); Science Foundation Ireland (SFI-CSET)