The study focused on Instruction Supervision Practices and Teachers’ Performance in Public Primary Schools in Bamunanika Subcounty in Luweero District. The objectives were: to examine the level of instructional supervision practices, to establish the level of teachers’ performance, and to examine the relationship between instructional supervision practices and teachers’ performance in selected primary schools in Bamunanika County, Luweero District. There was a high level of instructional supervision practices in selected primary schools in Bamunanika County, Luweero District as indicated with a grand mean of 3.45 and standard deviation of 1.018. A moderate level of teachers’ performance was found in selected primary schools in Bamunanika County, with a grand mean of 3.32 and standard deviation of 1.060. There is a relationship between instructional supervision practices and teacher’s performance in selected primary schools in Bamunanika County with r= 0.412 and p. value 0.000. The study hypothesized that there is no significant relationship between instructional supervision practices and teacher’s performance in selected primary schools in Bamunanika County, Luweero District. The study was based on descriptive and correlation research designs; data was gathered from 195 teachers using a self-administered questionnaire and 52 head teachers and Heads of Department were interviewed. The researcher recommended that: school administrators in public primary schools should ensure that they provide instructional supervision practices of lesson plan preparation, use of teaching –learning and class management. School administrators and teachers should work together to ensure high teacher performance in different areas where it was found to be weak or low.