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Maintenance contributes to gaining high business performance, guarantees system availability and reliability as well as safe and sustainable operations. Maintenance activity effectiveness depends on competences and the skills of operators whose performance strongly affects maintenance and production operations. The research field of human issues in industrial maintenance was deeply addressed in the literature; however, the current industrial paradigm, which focusses on the integration of new technologies in conventional manufacturing operations to support human performance, sheds light on new challenges for enterprises and opportunities for research in this field. While some literature reviews in the field of human errors and human factors are available, no study investigated the main topics, research trends and challenges related to the role of maintenance operators in manufacturing systems. This paper addresses the current state-of-the-art role of maintenance operators in manufacturing systems, providing an overview of the main studies. A systematic literature review was carried out to identify significant papers. Then, a topic modelling algorithm was used to detect the main topics of the selected papers to provide the research trends of the subject. The identified topics provided interesting research insights on the human role in industrial maintenance. Research trends and further research opportunities were defined.