Digital inequality scholarship has consistently found that people from varying societal positions experience digital media in their lives in divergent ways. Therefore, the growing body of research examining the relationship of social media use and well-being should account for the role of social inequality. This piece synthesizes key empirical research that has addressed the nexus of digital inequality, social media use, and well-being from one or more angles. Based on this extant scholarship, we develop a framework for research that integrates relevant perspectives from multiple disciplines.