Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

van der Loeff, Ina Schim; Voysey, Merryn; Clemens, Sue Ann Costa; Costa Clemens, Sue Ann; Madhi, Shabir A.; Weckx, Lily Y.; Folegatti, Pedro M.; Aley, Parvinder K.; Angus, Brian; Baillie, Vicky L.; Barnabas, Shaun L.; Green, Catherine M.; Bhorat, Qasim E.; Bibi, Sagida; Briner, Carmen; Green, Christopher A.; Cicconi, Paola; Clutterbuck, Elizabeth A.; Collins, Andrea M.; Cutland, Clare L.; Darton, Thomas C.; Dheda, Keertan; Dold, Christina; Duncan, Christopher J. Andrew; Emary, Katherine R. W.; Ewer, Katie J.; Flaxman, Amy; Fairlie, Lee; Faust, Saul N.; Feng, Shuo; Ferreira, Daniela M.; Finn, Adam; Galiza, Eva; Sa, Costa Clemens; Goodman, Anna L.; Greenland, Melanie; Hill, Catherine; Hill, Helen C.; Hirsch, Ian; Izu, Alane; Jenkin, Daniel; Joe, Carina C. D.; Kerridge, Simon; Koen, Anthonet; Kwatra, Gaurav; Lazarus, Rajeka; Sa, Madhi; Libri, Vincenzo; Lillie, Patrick J.; Marchevsky, Natalie G.; Marshall, Richard P.; Mendes, Ana V. A.; Milan, Eveline P.; Minassian, Angela M.; McGregor, Alastair; Mujadidi, Yama F.; Ly, Weckx; Nana, Anusha; Padayachee, Sherman D.; Phillips, Daniel J.; Pittella, Ana; Plested, Emma; Pm, Folegatti; Pollock, Katrina M.; Ramasamy, Maheshi N.; Ritchie, Adam J.; Robinson, Hannah; Schwarzbold, Alexandre V.; Smith, Andrew; Song, Rinn; Snape, Matthew D.; Sprinz, Eduardo; Sutherland, Rebecca K.; Thomson, Emma C.; Török, M. Estée; Pk, Aley; Toshner, Mark; Turner, David P. J.; Vekemans, Johan; Villafana, Tonya L.; White, Thomas; Williams, Christopher J.; Douglas, Alexander D.; Hill, Adrian V. S.; Lambe, Teresa; Gilbert, Sarah C.; Pollard, Andrew J.; Aban, Marites; Abeyskera, Kushala W. M.; Aboagye, Jeremy; Adam, Matthew; Adams, Kirsty; Adamson, James P.; Vl, Baillie; Adewatan, Gbadebo; Adlou, Syed; Ahmed, Khatija; Sl, Barnabas; Akhalwaya, Yasmeen; Akhalwaya, Saajida; Alcock, Andrew; Ali, Aabidah; Allen, Elizabeth R.; Allen, Lauren; Alvernaz, Felipe B.; Estée Török, M.; Amorim, Fabio Santos; Andrade, Claudia Sala; Andritsou, Foteini; Anslow, Rachel; Arbe-Barnes, Edward H.; Ariaans, Mark P.; Arns, Beatriz; Arruda, Laiana; Assad, Luiza; Azi, Paula De Almeida; Azi, Lorena De Almeida; Babbage, Gavin; Bailey, Catherine; Baker, Kenneth F.; Baker, Megan; Baker, Natalie; Baker, Philip; Baleanu, Ioana; Bandeira, Danieli; Bara, Anna; Qe, Bhorat; Barbosa, Marcella A. S.; Barker, Debbie; Barlow, Gavin D.; Barnes, Eleanor; Barr, Andrew S.; Barrett, Jordan R.; Barrett, Jessica; Barrett, Kelly; Bates, Louise; De Almeida Azi, Paula; Batten, Alexander; Beadon, Kirsten; Beales, Emily; Beckley, Rebecca; Belij-Rammerstorfer, Sandra; De Almeida Azi, Lorena; Bell, Jonathan; Bellamy, Duncan; Belton, Sue; Berg, Adam; Bermejo, Laura; Berrie, Eleanor; Berry, Lisa; Berzenyi, Daniella; Beveridge, Amy; Bewley, Kevin R.; Bharaj, Inderjeet; Bhikha, Sutika; Bhorat, Asad E.; Bhorat, Zaheda E.; Bijker, Else Margreet; Birch, Sarah; Birch, Gurpreet; Birchall, Kathryn; Bird, Adam; Bird, Olivia; Bisnauthsing, Karen; Bittaye, Mustapha; Blackwell, Luke; Blacow, Rachel; Bletchly, Heather; Blundell, Caitlin L.; Blundell, Susannah R.; Bodalia, Pritesh; Bolam, Emma; Boland, Elena; Bormans, Daan; Borthwick, Nicola; Bowring, Francesca; Boyd, Amy; Bradley, Penny; Brenner, Tanja; Bridges-Webb, Alice; Brown, Phillip; Brown, Claire; Brown-O'Sullivan, Charlie; Bruce, Scott; Brunt, Emily; Budd, William; Bulbulia, Yusuf A.; Bull, Melanie; Burbage, Jamie; Ritchie, Neil; Burn, Aileen; Buttigieg, Karen R.; Byard, Nicholas; Cabrera Puig, Ingrid; Calvert, Anna; Camara, Susana; Cao, Michelangelo; Cappuccini, Federica; Cardona, Rita; Cardoso, João R.; Carr, Melanie; Carroll, Miles W.; Carson-Stevens, Andrew; Carvalho, Yasmin de M.; Puig, Ingrid Cabrera; Casey, Helen R.; Cashen, Paul; Castro, Thais R. Y.; Castro, Lucia Carratala; Cathie, Katrina; Cavey, Ana; Cerbino-Neto, José; Cezar, Luiz Fernando F.; Green, Justin; Chadwick, Jim; Chanice, Chanice; Chapman, David; Charlton, Sue; Cheliotis, Katerina S.; Chelysheva, Irina; Chester, Oliver; Chiplin, Emily; Chita, Sunder; Cho, Jee-Sun; Cifuentes, Liliana; Clark, Elizabeth; Clark, Matthew; Colin-Jones, Rachel; Collins, Sarah L. K.; Colton, Hayley; Conlon, Christopher P.; Connarty, Sean; Coombes, Naomi; Cooper, Cushla; Cooper, Rachel; Cornelissen, Lynne; Corrah, Tumena; Cosgrove, Catherine A.; Costa, Fernanda Barroso; Cox, Tony; Crocker, Wendy E. M.; Crosbie, Sarah; Farias Da Guarda, Suzete N.; Cullen, Dan; Cunha, Debora R. M. F.; Cunningham, Christina J.; Cuthbertson, Fiona C.; da Costa, Daniel Marinho; Da Guarda, Suzete N. Farias; da Silva, Larissa P.; da Silva Moraes, Antonio Carlos; Damratoski, Brad E.; Danos, Zsofia; Dantas, Maria T. D. C.; Datoo, Mehreen S.; Datta, Chandrabali; Davids, Malika; Davies, Sarah L.; Davies, Kelly; Davies, Hannah; Davies, Sophie L.; Davies, Judith; Davis, Elizabeth J.; Davis, John; de Carvalho, José A. M.; Santos, Tannyth Gomes Dos; De Jager, Jeanne; de Jesus Jnr, Sergio; De Oliveira Kalid, Lis Moreno; Dearlove, David; Demissie, Tesfaye; Santos, Erika Pachecho Dos; Desai, Amisha; Di Marco, Stefania; Di Maso, Claudio; Dinesh, Tanya; Docksey, Claire; Dong, Tao; Donnellan, Francesca R.; Dos Santos, Tannyth Gomes; Dos Santos, Thainá G.; Dos Santos, Erika Pachecho; Douglas, Naomi; Downing, Charlotte; Drake, Jonathan; Drake-Brockman, Rachael; Drury, Ruth; Du Plessis, Joan; Dunachie, Susanna J.; Duncan, C. J. Andrew; Easom, Nicholas J. W.; Edwards, Mandy; Edwards, Nick J.; Edwards, Frances; El Muhanna, Omar M.; Da Silva, Carla Ferreira; Elias, Sean C.; Ellison-Handley, Branwen; Elmore, Michael J.; English, Marcus Rex; Esmail, Alisgair; Essack, Yakub Moosa; Farooq, Mutjaba; Fedosyuk, Sofiya; Felle, Sally; Ferguson, Susie; Ferreira Da Silva, Carla; Filho, Renato Furlan; Field, Samantha; Fisher, Richard; Fletcher, James; Fofie, Hazel; Fok, Henry; Ford, Karen J.; Fothergill, Ross; Fowler, Jamie; Fraiman, Pedro H. A.; Francis, Emma; Franco, Marilia M.; Frater, John; Freire, Marilúcia S. M.; Fry, Samantha H.; Fudge, Sabrina; Furlan Filho, Renato; Furze, Julie; Fuskova, Michelle; Galian-Rubio, Pablo; Garlant, Harriet; Gavrila, Madita; Gibbons, Karyna A.; Gilbride, Ciaran; Gill, Hardeep; Godwin, Kerry; Gokani, Karishma; Gonçalves, Maria Luisa Freire; Gonzalez, Isabela G. S.; Goodall, Jack; Goodwin, Jayne; Goondiwala, Amina; Gordon-Quayle, Katherine; Gorini, Giacomo; Goyanna, Alvaro; Grab, Janet; Gracie, Lara; Greenwood, Nicola; Greffrath, Johann; Groenewald, Marisa M.; Gunawardene, Anishka; Gupta, Gaurav; Hackett, Mark; Hallis, Bassam; Hamaluba, Mainga; Hamilton, Elizabeth; Hamlyn, Joseph; Hammersley, Daniel; Hanrath, Aidan T.; Hanumunthadu, Brama; Harris, Stephanie A.; Harris, Clair; Harrison, Thomas D.; Harrison, Daisy; Harris-Wright, Tara A.; Hart, Thomas C.; Hartnell, Birgit; Haughney, John; Hawkins, Sophia; Hayano, Laís Y. M.; Head, Ian; Heath, Paul T.; Henry, John Aaron; Hermosin Herrera, Macarena; Hettle, David B.; Higa, Cristhiane; Hill, Jennifer; Hodges, Gina; Hodgson, Susanne; Horne, Elizea; Hou, Mimi M.; Houlihan, Catherine F.; Howe, Elizabeth; Howell, Nicola; Hyder-Wright, Angela; Humphreys, Jonathan; Ikram, Sabina; Humphries, Holly E.; Ishwarbhai, Alka; Hurley, Katrina; Iveson, Poppy; Huson, Claire; Iyer, Vidyashankara; Hyams, Catherine; Jackson, Frederic; Jackson, Susan; Jaumdally, Shameem; Jeffers, Helen; Jesudason, Natasha; Jones, Carina; Jones, Christopher; Jones, Kathryn; Jones, Elizabeth; Jorge, Marianna Rocha; Joshi, Amar; Júnior, Eduardo A. M. S.; Kailath, Reshma; Kana, Faeeza; Kar, Arnab; Karampatsas, Konstantinos; Kasanyinga, Mwila; Kay, Linda; Keen, Jade; Kellett Wright, Johanna; Kelly, Elizabeth J.; Kelly, Debbie M.; Kelly, Dearbhla M.; Kelly, Sarah; Kerr, David; Khan, Liaquat; Khozoee, Baktash; Khurana, Ankush; Kidd, Sarah; Killen, Annabel; Kinch, Jasmin; Kinch, Patrick; King, Lloyd D. W.; King, Thomas B.; Kingham, Lucy; Klenerman, Paul; Kluczna, Diana M.; Knapper, Francesca; Knight, Julian C.; Knott, Daniel; Koleva, Stanislava; Lages, Pedro M.; Lang, Matilda; Lang, Gail; Larkworthy, Colin W.; Larwood, Jessica P. J.; Law, Rebecca; Lawrie, Alison M.; Lazarus, Erica M.; Leach, Amanda; Lees, Emily A.; Lelliott, Alice; Lemm, Nana-Marie; Lessa, Alvaro Edson Ramos; Leung, Stephanie; Li, Yuanyuan; Lias, Amelia M.; Liatsikos, Konstantinos; Linder, Aline; Lipworth, Samuel; Liu, Shuchang; Liu, Xinxue; Lloyd, Adam; Lloyd, Stephanie; Loew, Lisa; Lopez Ramon, Raquel; Lora, Leandro Bonecker; Wright, Johanna Kellett; Luz, Kleber Giovanni; MacDonald, Jonathan C.; MacGregor, Gordon; Madhavan, Meera; Mainwaring, David O.; Makambwa, Edson; Makinson, Rebecca; Malahleha, Mookho; Malamatsho, Ross; Mallett, Garry; Manning, Nicola; Mansatta, Kushal; Maoko, Takalani; Marinou, Spyridoula; Marlow, Emma; Marques, Gabriela N.; Marriott, Paula; Marshall, Julia L.; Masenya, Masebole; Masilela, Mduduzi; Masters, Shauna K.; Mathew, Moncy; Matlebjane, Hosea; Matshidiso, Kedidimetse; Mazur, Olga; Mazzella, Andrea; McCaughan, Hugh; McEwan, Joanne; McGlashan, Joanna; McInroy, Lorna; McRobert, Nicky; McSwiggan, Steve; Megson, Clare; Mehdipour, Savviz; Meijs, Wilma; Mendonça, Renata N. Õ.; Mentzer, Alexander J.; Mesquita, Ana Carolina F.; Miralhes, Patricia; Mirtorabi, Neginsadat; Ramon, Raquel Lopez; Mitton, Celia; Mnyakeni, Sibusiso; Moghaddas, Fiona; Molapo, Kgaogelo; Moloi, Mapule; Moore, Maria; Moran, Marni; Morey, Ella; Morgans, Róisín; Morris, Susan J.; Morris, Sheila; Morrison, Hazel; Morselli, Franca; Morshead, Gertraud; Morter, Richard; Mottay, Lynelle; Moultrie, Andrew; Moyo, Nathifa; Mpelembue, Mushiya; Msomi, Sibekezelo; Mugodi, Yvonne; Mukhopadhyay, Ekta; Muller, Jilly; Munro, Alasdair; Murphy, Sarah; Mweu, Philomena; Myerscough, Christopher; Naik, Gurudutt; Naker, Kush; Nastouli, Eleni; Ndlovu, Bongani; Nikolaou, Elissavet; Njenga, Cecilia; Noal, Helena C.; Noé, Andrés; Novaes, Gabrielle; Nugent, Fay L.; Nunes, Géssika Lanzillo A.; O'Brien, Katie; O'Connor, Daniel; Oelofse, Suzette; Oguti, Blanche; Olchawski, Victoria; Oldfield, Neil J.; Oliveira, Marianne G.; Oliveira, Catarina; Oliveira, Isabelle Silva Queiroz; Oommen-Jose, Aylin; Oosthuizen, Angela; O'Reilly, Paula; O'Reilly, Peter J.; Osborne, Piper; Owen, David R. J.; Owen, Lydia; Owens, Daniel; Owino, Nelly; Pacurar, Mihaela; Paiva, Brenda V. B.; Palhares, Edna M. F.; Palmer, Susan; Parracho, Helena M. R. T.; Parsons, Karen; Patel, Dipak; O′Brien, Katie; Patel, Bhumika; Patel, Faeezah; O′Connor, Daniel; Patrick-Smith, Maia; Payne, Ruth O.; Peng, Yanchun; Penn, Elizabeth J.; Pennington, Anna; Peralta Alvarez, Marco Polo; Pereira Stuchi, Bruno Pereira; Perez, Ana Luiza; O′Reilly, Paula; Perinpanathan, Tanaraj; Perring, James; Perumal, Rubeshan; Petkar, Sahir Yusuf; Philip, Tricia; Phillips, Jennifer; Phohu, Mary Kgomotso; Pickup, Lorinda; O′Reilly, Peter J.; Pieterse, Sonja; Pinheiro, Jessica Morgana; Piper, Jo; Pipini, Dimitra; Plank, Mary; Plant, Sinéad; Pollard, Samuel; Pooley, Jennifer; Pooran, Anil; Poulton, Ian; Powers, Claire; Presa, Fernando B.; Price, David A.; Price, Vivien; Primeira, Marcelo R.; Proud, Pamela C.; Provstgaard-Morys, Samuel; Stuchi, Bruno Pereira Pereira; Pueschel, Sophie; Pulido, David; Quaid, Sheena; Rabara, Ria; Radia, Kajal; Rajapaska, Durga; Rajeswaran, Thurkka; Ramos, Leonardo; Ramos, Alberto San Francisco; Ramos Lopez, Fernando; Rampling, Tommy; Rand, Jade; Ratcliffe, Helen; Rawlinson, Tom; Rea, David; Rees, Byron; Resuello-Dauti, Mila; Reyes Pabon, Emilia; Rhead, Sarah; Riaz, Tawassal; Ricamara, Marivic; Pabon, Emilia Reyes; Richards, Alexander; Richter, Alex; Robbins, Alexander J.; Green, C. M.; Roberts, Hannah; Robinson, Ryan E.; Roche, Sophie; Rollier, Christine; Rose, Louisa; Ross Russell, Amy L.; Rossouw, Lindie; Royal, Simon; Rudiansyah, Indra; Ryalls, Kim; Green, C. A.; Sabine, Charlotte; Saich, Stephen; Sale, Jessica C.; Salman, Ahmed M.; Salvador, Natalia; Salvador, Stephannie; Sampaio, Milla Dias; Samson, Annette D.; Sanchez-Gonzalez, Amada; Sanders, Helen; Sanders, Katherine; Santos, Erika; Santos Guerra, Mayara F. S.; Satti, Iman; Saunders, Jack E.; Saunders, Caroline; Sayed, Aakifah Bibi Arif; Schim van der Loeff, Ina; Schmid, Annina B.; Schofield, Ella; Screaton, Gavin R.; Seddiqi, Samiullah; Segireddy, Rameswara R.; Senger, Roberta; Serrano, Sonia; Shaik, Imam; Sharpe, Hannah R.; Sharrocks, Katherine; Shaw, Robert; Shea, Adam; Alvarez, Marco Polo Peralta; Sheehan, Emma; Shepherd, Amy; Shiham, Farah; Silk, Sarah E.; Silva-Reyes, Laura; Silveira, Lidiana B. T. D.; Silveira, Mariana B. V.; Singh, Nisha; Sinha, Jaisi; Skelly, Donal T.; Smith, Daniel C.; Smith, Nick; Smith, Holly E.; Smith, David J.; Smith, Catherine C.; Soares, Airanuédida S.; Solórzano, Carla; Sorio, Guilherme L.; Lopez, Thamyres Souza; Sorley, Kim; Sosa-Rodriguez, Tiffany; Souza, Cinthia M. C. D. L.; Souza, Bruno S. D. F.; Souza, Alessandra R.; Souza Lopez, Thamyres; Sowole, Luciana; Spencer, Alexandra J.; Spoors, Louise; Stafford, Lizzie; Stamford, Imogen; Stein, Ricardo; Stockdale, Lisa; Stockwell, Lisa V.; Strickland, Louise H.; Stuart, Arabella; Sturdy, Ann; Sutton, Natalina; Szigeti, Anna; Tahiri-Alaoui, Abdessamad; Tanner, Rachel; Taoushanis, Carol; Tarr, Alexander W.; Tarrant, Richard; Taylor, Keja; Taylor, Ursula; Taylor, Iona Jennifer; Taylor, Justin; te Water Naude, Rebecca; Templeton, Kate; Naude, Rebecca te Water; Themistocleous, Yrene; Themistocleous, Andreas; Thomas, Merin; Thomas, Kelly; Thomas, Tonia M.; Thombrayil, Asha; Thompson, Julia; Thompson, Fawziyah; Thompson, Ameeka; Thompson, Amber; Thompson, Kevin; Thornton-Jones, Viv; Thotusi, Larissa H. S.; Tighe, Patrick J.; Tinoco, Lygia Accioly; Tiongson, Gerlynn Ferreras; Tladinyane, Bonolo; Tomasicchio, Michele; Tomic, Adriana; Tonks, Susan; Towner, James; Tran, Nguyen; Tree, Julia A.; Trillana, Gerry; Trinham, Charlotte; Trivett, Rose; Truby, Adam; Tsheko, Betty Lebogang; Tubb, Philippa; Turabi, Aadil; Turner, Richard; Turner, Cheryl; Turner, Nicola; Tyagi, Bhavya; Ulaszewska, Marta; Underwood, Benjamin R.; van Eck, Samual; Varughese, Rachel; Verbart, Dennis; Verheul, Marije K.; Walker, Gemma; Vichos, Iason; Walker, Laura; Vieira, Taiane A.; Wand, Matthew E.; Wardell, Theresa; Warimwe, George M.; Warren, Sarah C.; Watkins, Bridget; Watson, Marion E. E.; Watson, Ekaterina; Webb, Stewart; Webster, Angela; Welch, Jessica; Wellbelove, Zoe; Wells, Jeanette H.; West, Alison J.; White, Beth; White, Caroline; White, Rachel; Williams, Paul; Williams, Rachel L.; Willingham, Silvia; Winslow, Rebecca; Woods, Danielle; Woodyer, Mark; Worth, Andrew T.; Wright, Danny; Wroblewska, Marzena; Yao, Andy; Yim, Yee Ting Nicole; Zambrano, Marina Bauer; Zimmer, Rafael Leal; Zizi, Dalila; Zuidewind, Peter; Group, Oxford Covid Vaccine Trial

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Pedro Folegatti
van der Loeff et al., 2021

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Elsevier, The Lancet, 10277(397), p. 881-891, 2021

DOI: 10.1016/s0140-6736(21)00432-3

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@article{van der Loeff2021,
  author = {van der Loeff, Ina Schim and Voysey, Merryn and Clemens, Sue Ann Costa and Costa Clemens, Sue Ann and Madhi, Shabir A. and Weckx, Lily Y. and Folegatti, Pedro M. and Aley, Parvinder K. and Angus, Brian and Baillie, Vicky L. and Barnabas, Shaun L. and Green, Catherine M. and Bhorat, Qasim E. and Bibi, Sagida and Briner, Carmen and Green, Christopher A. and Cicconi, Paola and Clutterbuck, Elizabeth A. and Collins, Andrea M. and Cutland, Clare L. and Darton, Thomas C. and Dheda, Keertan and Dold, Christina and Duncan, Christopher J. Andrew and Emary, Katherine R. W. and Ewer, Katie J. and Flaxman, Amy and Fairlie, Lee and Faust, Saul N. and Feng, Shuo and Ferreira, Daniela M. and Finn, Adam and Galiza, Eva and Sa, Costa Clemens and Goodman, Anna L. and Greenland, Melanie and Hill, Catherine and Hill, Helen C. and Hirsch, Ian and Izu, Alane and Jenkin, Daniel and Joe, Carina C. D. and Kerridge, Simon and Koen, Anthonet and Kwatra, Gaurav and Lazarus, Rajeka and Sa, Madhi and Libri, Vincenzo and Lillie, Patrick J. and Marchevsky, Natalie G. and Marshall, Richard P. and Mendes, Ana V. A. and Milan, Eveline P. and Minassian, Angela M. and McGregor, Alastair and Mujadidi, Yama F. and Ly, Weckx and Nana, Anusha and Padayachee, Sherman D. and Phillips, Daniel J. and Pittella, Ana and Plested, Emma and Pm, Folegatti and Pollock, Katrina M. and Ramasamy, Maheshi N. and Ritchie, Adam J. and Robinson, Hannah and Schwarzbold, Alexandre V. and Smith, Andrew and Song, Rinn and Snape, Matthew D. and Sprinz, Eduardo and Sutherland, Rebecca K. and Thomson, Emma C. and Török, M. Estée and Pk, Aley and Toshner, Mark and Turner, David P. J. and Vekemans, Johan and Villafana, Tonya L. and White, Thomas and Williams, Christopher J. and Douglas, Alexander D. and Hill, Adrian V. S. and Lambe, Teresa and Gilbert, Sarah C. and Pollard, Andrew J. and Aban, Marites and Abeyskera, Kushala W. M. and Aboagye, Jeremy and Adam, Matthew and Adams, Kirsty and Adamson, James P. and Vl, Baillie and Adewatan, Gbadebo and Adlou, Syed and Ahmed, Khatija and Sl, Barnabas and Akhalwaya, Yasmeen and Akhalwaya, Saajida and Alcock, Andrew and Ali, Aabidah and Allen, Elizabeth R. and Allen, Lauren and Alvernaz, Felipe B. and Estée Török, M. and Amorim, Fabio Santos and Andrade, Claudia Sala and Andritsou, Foteini and Anslow, Rachel and Arbe-Barnes, Edward H. and Ariaans, Mark P. and Arns, Beatriz and Arruda, Laiana and Assad, Luiza and Azi, Paula De Almeida and Azi, Lorena De Almeida and Babbage, Gavin and Bailey, Catherine and Baker, Kenneth F. and Baker, Megan and Baker, Natalie and Baker, Philip and Baleanu, Ioana and Bandeira, Danieli and Bara, Anna and Qe, Bhorat and Barbosa, Marcella A. S. and Barker, Debbie and Barlow, Gavin D. and Barnes, Eleanor and Barr, Andrew S. and Barrett, Jordan R. and Barrett, Jessica and Barrett, Kelly and Bates, Louise and De Almeida Azi, Paula and Batten, Alexander and Beadon, Kirsten and Beales, Emily and Beckley, Rebecca and Belij-Rammerstorfer, Sandra and De Almeida Azi, Lorena and Bell, Jonathan and Bellamy, Duncan and Belton, Sue and Berg, Adam and Bermejo, Laura and Berrie, Eleanor and Berry, Lisa and Berzenyi, Daniella and Beveridge, Amy and Bewley, Kevin R. and Bharaj, Inderjeet and Bhikha, Sutika and Bhorat, Asad E. and Bhorat, Zaheda E. and Bijker, Else Margreet and Birch, Sarah and Birch, Gurpreet and Birchall, Kathryn and Bird, Adam and Bird, Olivia and Bisnauthsing, Karen and Bittaye, Mustapha and Blackwell, Luke and Blacow, Rachel and Bletchly, Heather and Blundell, Caitlin L. and Blundell, Susannah R. and Bodalia, Pritesh and Bolam, Emma and Boland, Elena and Bormans, Daan and Borthwick, Nicola and Bowring, Francesca and Boyd, Amy and Bradley, Penny and Brenner, Tanja and Bridges-Webb, Alice and Brown, Phillip and Brown, Claire and Brown-O'Sullivan, Charlie and Bruce, Scott and Brunt, Emily and Budd, William and Bulbulia, Yusuf A. and Bull, Melanie and Burbage, Jamie and Ritchie, Neil and Burn, Aileen and Buttigieg, Karen R. and Byard, Nicholas and Cabrera Puig, Ingrid and Calvert, Anna and Camara, Susana and Cao, Michelangelo and Cappuccini, Federica and Cardona, Rita and Cardoso, João R. and Carr, Melanie and Carroll, Miles W. and Carson-Stevens, Andrew and Carvalho, Yasmin de M. and Puig, Ingrid Cabrera and Casey, Helen R. and Cashen, Paul and Castro, Thais R. Y. and Castro, Lucia Carratala and Cathie, Katrina and Cavey, Ana and Cerbino-Neto, José and Cezar, Luiz Fernando F. and Green, Justin and Chadwick, Jim and Chanice, Chanice and Chapman, David and Charlton, Sue and Cheliotis, Katerina S. and Chelysheva, Irina and Chester, Oliver and Chiplin, Emily and Chita, Sunder and Cho, Jee-Sun and Cifuentes, Liliana and Clark, Elizabeth and Clark, Matthew and Colin-Jones, Rachel and Collins, Sarah L. K. and Colton, Hayley and Conlon, Christopher P. and Connarty, Sean and Coombes, Naomi and Cooper, Cushla and Cooper, Rachel and Cornelissen, Lynne and Corrah, Tumena and Cosgrove, Catherine A. and Costa, Fernanda Barroso and Cox, Tony and Crocker, Wendy E. M. and Crosbie, Sarah and Farias Da Guarda, Suzete N. and Cullen, Dan and Cunha, Debora R. M. F. and Cunningham, Christina J. and Cuthbertson, Fiona C. and da Costa, Daniel Marinho and Da Guarda, Suzete N. Farias and da Silva, Larissa P. and da Silva Moraes, Antonio Carlos and Damratoski, Brad E. and Danos, Zsofia and Dantas, Maria T. D. C. and Datoo, Mehreen S. and Datta, Chandrabali and Davids, Malika and Davies, Sarah L. and Davies, Kelly and Davies, Hannah and Davies, Sophie L. and Davies, Judith and Davis, Elizabeth J. and Davis, John and de Carvalho, José A. M. and Santos, Tannyth Gomes Dos and De Jager, Jeanne and de Jesus Jnr, Sergio and De Oliveira Kalid, Lis Moreno and Dearlove, David and Demissie, Tesfaye and Santos, Erika Pachecho Dos and Desai, Amisha and Di Marco, Stefania and Di Maso, Claudio and Dinesh, Tanya and Docksey, Claire and Dong, Tao and Donnellan, Francesca R. and Dos Santos, Tannyth Gomes and Dos Santos, Thainá G. and Dos Santos, Erika Pachecho and Douglas, Naomi and Downing, Charlotte and Drake, Jonathan and Drake-Brockman, Rachael and Drury, Ruth and Du Plessis, Joan and Dunachie, Susanna J. and Duncan, C. J. Andrew and Easom, Nicholas J. W. and Edwards, Mandy and Edwards, Nick J. and Edwards, Frances and El Muhanna, Omar M. and Da Silva, Carla Ferreira and Elias, Sean C. and Ellison-Handley, Branwen and Elmore, Michael J. and English, Marcus Rex and Esmail, Alisgair and Essack, Yakub Moosa and Farooq, Mutjaba and Fedosyuk, Sofiya and Felle, Sally and Ferguson, Susie and Ferreira Da Silva, Carla and Filho, Renato Furlan and Field, Samantha and Fisher, Richard and Fletcher, James and Fofie, Hazel and Fok, Henry and Ford, Karen J. and Fothergill, Ross and Fowler, Jamie and Fraiman, Pedro H. A. and Francis, Emma and Franco, Marilia M. and Frater, John and Freire, Marilúcia S. M. and Fry, Samantha H. and Fudge, Sabrina and Furlan Filho, Renato and Furze, Julie and Fuskova, Michelle and Galian-Rubio, Pablo and Garlant, Harriet and Gavrila, Madita and Gibbons, Karyna A. and Gilbride, Ciaran and Gill, Hardeep and Godwin, Kerry and Gokani, Karishma and Gonçalves, Maria Luisa Freire and Gonzalez, Isabela G. S. and Goodall, Jack and Goodwin, Jayne and Goondiwala, Amina and Gordon-Quayle, Katherine and Gorini, Giacomo and Goyanna, Alvaro and Grab, Janet and Gracie, Lara and Greenwood, Nicola and Greffrath, Johann and Groenewald, Marisa M. and Gunawardene, Anishka and Gupta, Gaurav and Hackett, Mark and Hallis, Bassam and Hamaluba, Mainga and Hamilton, Elizabeth and Hamlyn, Joseph and Hammersley, Daniel and Hanrath, Aidan T. and Hanumunthadu, Brama and Harris, Stephanie A. and Harris, Clair and Harrison, Thomas D. and Harrison, Daisy and Harris-Wright, Tara A. and Hart, Thomas C. and Hartnell, Birgit and Haughney, John and Hawkins, Sophia and Hayano, Laís Y. M. and Head, Ian and Heath, Paul T. and Henry, John Aaron and Hermosin Herrera, Macarena and Hettle, David B. and Higa, Cristhiane and Hill, Jennifer and Hodges, Gina and Hodgson, Susanne and Horne, Elizea and Hou, Mimi M. and Houlihan, Catherine F. and Howe, Elizabeth and Howell, Nicola and Hyder-Wright, Angela and Humphreys, Jonathan and Ikram, Sabina and Humphries, Holly E. and Ishwarbhai, Alka and Hurley, Katrina and Iveson, Poppy and Huson, Claire and Iyer, Vidyashankara and Hyams, Catherine and Jackson, Frederic and Jackson, Susan and Jaumdally, Shameem and Jeffers, Helen and Jesudason, Natasha and Jones, Carina and Jones, Christopher and Jones, Kathryn and Jones, Elizabeth and Jorge, Marianna Rocha and Joshi, Amar and Júnior, Eduardo A. M. 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F. and Souza, Alessandra R. and Souza Lopez, Thamyres and Sowole, Luciana and Spencer, Alexandra J. and Spoors, Louise and Stafford, Lizzie and Stamford, Imogen and Stein, Ricardo and Stockdale, Lisa and Stockwell, Lisa V. and Strickland, Louise H. and Stuart, Arabella and Sturdy, Ann and Sutton, Natalina and Szigeti, Anna and Tahiri-Alaoui, Abdessamad and Tanner, Rachel and Taoushanis, Carol and Tarr, Alexander W. and Tarrant, Richard and Taylor, Keja and Taylor, Ursula and Taylor, Iona Jennifer and Taylor, Justin and te Water Naude, Rebecca and Templeton, Kate and Naude, Rebecca te Water and Themistocleous, Yrene and Themistocleous, Andreas and Thomas, Merin and Thomas, Kelly and Thomas, Tonia M. and Thombrayil, Asha and Thompson, Julia and Thompson, Fawziyah and Thompson, Ameeka and Thompson, Amber and Thompson, Kevin and Thornton-Jones, Viv and Thotusi, Larissa H. S. and Tighe, Patrick J. and Tinoco, Lygia Accioly and Tiongson, Gerlynn Ferreras and Tladinyane, Bonolo and Tomasicchio, Michele and Tomic, Adriana and Tonks, Susan and Towner, James and Tran, Nguyen and Tree, Julia A. and Trillana, Gerry and Trinham, Charlotte and Trivett, Rose and Truby, Adam and Tsheko, Betty Lebogang and Tubb, Philippa and Turabi, Aadil and Turner, Richard and Turner, Cheryl and Turner, Nicola and Tyagi, Bhavya and Ulaszewska, Marta and Underwood, Benjamin R. and van Eck, Samual and Varughese, Rachel and Verbart, Dennis and Verheul, Marije K. and Walker, Gemma and Vichos, Iason and Walker, Laura and Vieira, Taiane A. and Wand, Matthew E. and Wardell, Theresa and Warimwe, George M. and Warren, Sarah C. and Watkins, Bridget and Watson, Marion E. E. and Watson, Ekaterina and Webb, Stewart and Webster, Angela and Welch, Jessica and Wellbelove, Zoe and Wells, Jeanette H. and West, Alison J. and White, Beth and White, Caroline and White, Rachel and Williams, Paul and Williams, Rachel L. and Willingham, Silvia and Winslow, Rebecca and Woods, Danielle and Woodyer, Mark and Worth, Andrew T. and Wright, Danny and Wroblewska, Marzena and Yao, Andy and Yim, Yee Ting Nicole and Zambrano, Marina Bauer and Zimmer, Rafael Leal and Zizi, Dalila and Zuidewind, Peter and Group, Oxford Covid Vaccine Trial},
  doi = {10.1016/s0140-6736(21)00432-3},
  journal = {The Lancet},
  month = {feb},
  pages = {881-891},
  title = {Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials},
  url = {https://oadoi.org/10.1016/s0140-6736(21)00432-3},
  volume = {397},
  year = {2021}
}

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