Published in

Antibody Therapeutics, 2021

DOI: 10.1093/abt/tbab003

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Optimization of Therapeutic Antibodies

Journal article published in 2021 by Bo Wang, Sachith Gallolu Kankanamalage, Jianbo Dong, Yue Liu
Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

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Abstract

Abstract In this review, we have summarized the current landscape of therapeutic antibody optimization for successful development. By engineering antibodies with display technology, computer-aided design and site mutagenesis, various properties of the therapeutic antibody candidates can be improved with the purpose of enhancing their safety, efficacy and developability. These properties include antigen binding affinity and specificity, biological efficacy, pharmacokinetics and pharmacodynamics, immunogenicity, and physico-chemical developability features. A best-in-class strategy may require the optimization of all these properties to generate a good therapeutic antibody.