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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 3(65), 2021

DOI: 10.1128/aac.01554-20

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Optimization of fluconazole dosing for the prevention and treatment of invasive candidiasis based on the pharmacokinetics of fluconazole in critically-ill patients

Journal article published in 2020 by J. M. Boonstra, A. G. Märtson ORCID, I. Sandaradura ORCID, J. G. W. Kosterink, T. S. van der Werf, D. J. E. Marriott, J. G. Zijlstra, D. J. Touw, J. W. C. Alffenaar ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The efficacy of fluconazole is related to the area under the plasma concentration-time curve (AUC) over the MIC of the microorganism. Physiological changes in critically ill patients may affect the exposure of fluconazole, and therefore dosing adjustments might be needed.