Published in

Wiadomości Lekarskie, 8(72), p. 1566-1570, 2019

DOI: 10.36740/wlek201908126

Links

Tools

Export citation

Search in Google Scholar

The Role of 1,25(oh)2d3 and Its Analogs in Proliferation and Differentiation of Squamous Cell Carcinoma of the Head and Neck – Literature Review

Journal article published in 2019 by Mateusz Mizgalski, Krzysztof Zub, Karolina Dorobisz ORCID, Tomasz Zatoński
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

Full text: Unavailable

Question mark in circle
Preprint: policy unknown
Upload
Question mark in circle
Postprint: policy unknown
Upload
Question mark in circle
Published version: policy unknown
Upload

Abstract

Epidemiological studies correlate sun or UV light exposure with a lower incidence of a variety of malignancies, including breast, colon and prostate cancer. The biologically active 1,25(OH)2D3 and its analogs have been shown to have antiproliferative and differentiating effects in a variety of malignant and non-malignant cells. The effects of 1,25(OH)2D3 are mediated by the binding of calcitriol to a specific intracellular receptor, vitamin D receptor [VDR]. The aim of this study is to review the literature concerning the role of 1,25(OH)2D3 and its analogs in squamous carcinoma cell lines of the head and neck (SCCHN).