Abstract Quality consistency is essential in maximizing the productivity rate of the injection molding process and minimizing the production cost. The quality consistency problem is particularly acute in the case of injection molding processes performed using regrind resin, for which the rheological properties are less uniform and more unpredictable than those of virgin material. Accordingly, the present study proposes a two-stage approach for optimizing the injection molding process parameters in such a way as to achieve a consistent molding quality over repeated injection molding cycles. In the first stage, the values of the injection speed/pressure, velocity-to-pressure (V/P) switchover point, and packing pressure are individually determined based on an inspection of the cavity pressure profile and machine parameters provided by the injection molding machine controller. In the second stage, a robust parametric search method based on a first-order regression model is employed to determine the optimal combination of the process parameter settings. Using an Integrated Circuit (IC) tray fabricated from regrind resin for illustration purposes, the results confirm that the proposed method overcomes the problem of small variations in the melt quality and therefore provides an effective technique for improving the yield rate and quality of the continuous mass production.