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ASME 2012 Summer Bioengineering Conference, Parts A and B

DOI: 10.1115/sbc2012-80426

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Mechanical chondrocyte damage thresholds

Proceedings article published in 2012 by Mc Mark van Turnhout, Mark C. van Turnhout ORCID, Stefan A. H. de Vries, Sah Stefan de Vries, Corrinus C. van Donkelaar, Cc René van Donkelaar, Cwj Cees Oomens, Cees W. J. Oomens
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This paper is available in a repository.

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Abstract

Chondrocyte content in articular cartilage is very low. Only 2% to 5% of the tissue volume consists of chondrocytes [1]. Yet, these cells are responsible for maintenance of the tissue. Hence, the loss of chondrocytes that is often occurring at an early stage of cartilage degeneration is detrimental to articular cartilage. Excessive mechanical loading is known to be a cause of cell death. However, mechanical thresholds beyond which chondrocyte apoptosis would be induced are unknown.