Published in
Royal Society of Chemistry, Dalton Transactions, 45(49), p. 16425-16439, 2020
DOI: 10.1039/d0dt01389g
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Investigation of Cobalt(III)-Phenylalanine Complexes for Hypoxia-activated Drug Delivery
Journal article published in 2020 by
Isabela Cristina Aguiar de Souza 
,
Savyo Souza Santana,
Savyo de Souza Santana ,
Javier G. Gomez,
Javier G. Gómez ,
Guilherme P. Guedes ,
João Madureira ,
Susana Maria de Ornelas Quintal ,
Mauricio Lanznaster
,
Savyo Souza Santana,
Savyo de Souza Santana ,
Javier G. Gomez,
Javier G. Gómez ,
Guilherme P. Guedes ,
João Madureira ,
Susana Maria de Ornelas Quintal ,
Mauricio Lanznaster
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Abstract
l-Phenylalanine (l-Phe) was used as a ligand model for the anticancer drug melphalan. CoIII–Phe complexes were successfully designed for hypoxia-selective release of l-Phe from CoIII–Phe upon Co3+/Co2+ reduction by ascorbic acid.