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Wiley, FEBS Letters, 1-2(275), p. 39-43, 1990

DOI: 10.1016/0014-5793(90)81434-p

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Protein phosphatase 1 activity inDrosophilamutants with abnormalities in mitosis and chromosome condensation

Journal article published in 1990 by Viktor Dombrádi, J. Myles Axton ORCID, Hazel M. Barker, Patricia T. W. Cohen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A Drosophila gene encoding a protein phosphatase 1 (PP1) has been sequenced, and lethal mutations in this locus (87B) analysed. Two mutants (ck19e211 and ck19hs46), which disrupt mitosis, lack the 87B isoenzyme and express only approximately 20% of wild type PP1 activity. The promoter region of the gene is deleted in the ck19e211 mutant. A third mutant (ck19e078), which shows suppression of position effect variegation, but has little effect on mitosis, possesses approximately 35% of wild type PP1 activity. The results indicate that the PP1 87B isoenzyme is involved in regulation of chromosome condensation at interphase as well as mitosis.