Royal Society of Chemistry, Chemical Communications, 32(56), p. 4476-4479, 2020
DOI: 10.1039/d0cc01485k
Full text: Unavailable
We have identified a proteolysis targeting chimera (PROTAC) of class I HDACs 1, 2 and 3. Our PROTAC decreased HDAC 1, 2 & 3 protein abundance, increased histone acetylation levels and compromised colon cancer HCT116 cell viability.