Published in
Royal Society of Chemistry, Chemical Communications, 41(56), p. 5496-5499, 2020
DOI: 10.1039/d0cc00444h
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Consecutive 5′- and 3′-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response
Journal article published in 2020 by
Sven Epple 
,
Cameron Thorpe ,
Ysobel R. Baker ,
Afaf H. El-Sagheer ,
Tom Brown
,
Cameron Thorpe ,
Ysobel R. Baker ,
Afaf H. El-Sagheer ,
Tom Brown
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Abstract
The combination of amide coupling with standard oligonucleotide synthesis enables assembly of reduced charge chimeric gapmer antisense oligonucleotides that trigger an efficient RNase H response while improving serum lifetime and cellular uptake.