SUMMARY The Greater Geneva Basin (GGB), located in southwestern Switzerland and neighboring France, is enclosed by the rotating northwestern edge of the Alpine front and the Jura mountains chain. Recently, this basin has received increasing attention as a target for geothermal exploration. Historical and instrumental seismicity suggest that faults affecting the basin may still be active. Moderate-magnitude earthquakes have been located along the Vuache fault, a major strike-slip structure crossing the basin. Before geothermal exploration starts, it is key to evaluate the seismic rate in the region and identify possible seismogenic areas. In this context, we deployed a temporary seismic network of 20 broad-band stations (from September 2016 to January 2018) to investigate the ongoing seismic activity, its relationship with local tectonic structures, and the large-scale kinematics of the area. Our network lowered the magnitude of completeness of the permanent Swiss and French networks from 2.0 to a theoretical value of 0.5. Using a new coherence-based detector (LASSIE - particularly effective to detect microseismicity in noisy environments), we recorded scarce seismicity in the basin with local magnitudes ranging from 0.7 to 2.1 ML. No earthquakes were found in the Canton of Geneva where geothermal activities will take place. We constructed a local ’minimum 1-D P-wave velocity model’ adapted to the GGB using earthquakes from surrounding regions. We relocated the events of our catalogue obtaining deeper hypocentres compared to the locations obtained using the available regional velocity models. We also retrieved eight new focal mechanisms using a combination of polarities and waveform inversion techniques (CSPS). The stress inversion shows a pure strike-slip stress regime, which is in agreement with structural and geological data. Combining the background seismicity with our catalogue, we identified seismogenic areas offsetting the basin.