Published in
American Association for the Advancement of Science, Science Advances, 5(6), 2020
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Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity
Journal article published in 2020 by
Tao Ni 
,
Fang Jiao ,
Xiulian Yu ,
Saša Aden ,
Lucy Ginger,
Sophie I. Williams ,
Fangfang Bai,
Vojtěch Pražák ,
Dimple Karia ,
Phillip Stansfeld ,
Peijun Zhang ,
George Munson ,
Gregor Anderluh ,
Simon Scheuring ,
Robert J. C. Gilbert
,
Fang Jiao ,
Xiulian Yu ,
Saša Aden ,
Lucy Ginger,
Sophie I. Williams ,
Fangfang Bai,
Vojtěch Pražák ,
Dimple Karia ,
Phillip Stansfeld ,
Peijun Zhang ,
George Munson ,
Gregor Anderluh ,
Simon Scheuring ,
Robert J. C. Gilbert
This paper is made freely available by the publisher.
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Abstract
Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.