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Oxford University Press, Brain, 10(142), p. 3243-3264, 2019

DOI: 10.1093/brain/awz241

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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.

Journal article published in 2019 by Peter de Boer, Renzo Mancuso, Gemma Fryatt, Madeleine Cleal, Juliane Obst, Elena Pipi, Jimena Monzón-Sandoval, Laura Winchester, Elena M. Ribe, Eva Daniela Ruiz, Alejo Nevado, Tom Jacobs, Edward T. Bullmore, Junaid Bhatti, Nigel Austin and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Microglia have been implicated in amyloid beta-induced neuropathology, but their role in tau-induced neurodegeneration remains unclear. Mancuso et al. report that blockade of microglial proliferation by CSF1R inhibitor JNJ-40346527 modifies brain inflammation and ameliorates disease progression in P301S tauopathy mice. CSF1R inhibition may have therapeutic potential in tau-mediated neurodegenerative diseases.