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Elsevier, Cell, 4(157), p. 992-992.e1, 2014

DOI: 10.1016/j.cell.2014.04.027

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SnapShot: Epithelial tight junctions.

Journal article published in 2014 by Karl Matter, Maria S. Balda
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

Tight junctions form a morphological and functional border between the apical and basolateral cell surface domains that serves as a paracellular diffusion barrier, enabling epithelial cells to separate compartments of different composition. Tight junctions also contribute to the generation and maintenance of cell polarity and regulate signaling mechanisms that guide cell behavior, shape, and gene expression. This SnapShot illustrates their components, organization, and functions.