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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(63), 2019

DOI: 10.1128/aac.01426-19

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Exploring Aztreonam in Combination with Ceftazidime-Avibactam or Meropenem-Vaborbactam as Potential Treatments for Metallo- and Serine-β-Lactamase-Producing Enterobacteriaceae

Journal article published in 2019 by M. Biagi, T. Wu, M. Lee, S. Patel ORCID, D. Butler, E. Wenzler ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Data provided by SHERPA/RoMEO

Abstract

Metallo-β-lactamase (MBL)-producing Enterobacteriaceae , particularly those that coharbor serine β-lactamases, are a serious emerging public health threat given their rapid dissemination and the limited number of treatment options. Preclinical and anecdotal clinical data support the use of aztreonam in combination with ceftazidime-avibactam against these pathogens, but other aztreonam-based combinations have not been explored.