Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia
Journal article published in 2019 by
Michael Broux 
,
Cristina Prieto ,
Sofie Demeyer ,
Marlies Vanden Bempt ,
Llucia Alberti-Servera ,
Inge Lodewijckx,
Roel Vandepoel ,
Nicole Mentens,
Olga Gielen,
Kris Jacobs,
Ellen Geerdens,
Carmen Vicente ,
Charles E. de Bock ,
Jan Cools
,
Cristina Prieto ,
Sofie Demeyer ,
Marlies Vanden Bempt ,
Llucia Alberti-Servera ,
Inge Lodewijckx,
Roel Vandepoel ,
Nicole Mentens,
Olga Gielen,
Kris Jacobs,
Ellen Geerdens,
Carmen Vicente ,
Charles E. de Bock ,
Jan Cools
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Abstract
Key Points Suz12 inactivation cooperates with JAK3 mutant signaling to drive T-ALL development. JAK3/Suz12 mutant leukemia cells show increased sensitivity to PI3K/mTOR, VEGF receptor, and HSP90 inhibitors.