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American Diabetes Association, Diabetes Care, 8(38), p. 1456-1466

DOI: 10.2337/dc14-2709



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Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits

Journal article published in 2015 by Hassan S. Dashti ORCID, Jack L. Follis, Caren E. Smith, Toshiko Tanaka, Marta Garaulet, Daniel J. Gottlieb, Adela Hruby, Paul F. Jacques, Jessica C. Kiefte-De Jong ORCID, Stefania Lamon-Fava, Frank A. J. L. Scheer, Mia-Maria Perälä, Traci M. Bartz, Leena Kovanen, Rozenn N. Lemaitre and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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OBJECTIVE Common circadian-related gene variants associate with increased risk for metabolic alterations including type 2 diabetes. However, little is known about whether diet and sleep could modify associations between circadian-related variants (CLOCK-rs1801260, CRY2-rs11605924, MTNR1B-rs1387153, MTNR1B-rs10830963, NR1D1-rs2314339) and cardiometabolic traits (fasting glucose [FG], HOMA-insulin resistance, BMI, waist circumference, and HDL-cholesterol) to facilitate personalized recommendations. RESEARCH DESIGN AND METHODS We conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations and interactions between dietary intake/sleep duration and selected variants on cardiometabolic traits from 15 cohort studies including up to 28,190 participants of European descent from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. RESULTS We observed significant associations between relative macronutrient intakes and glycemic traits and short sleep duration (