Abstract Purpose Performance standards for quantitative ¹⁸F-FDG PET/CT studies are provided by the EANM Research Ltd. (EARL) to enable comparability of quantitative PET in multicentre studies. Yet, such specifications are not available for ⁶⁸Ga. Therefore, our aim was to evaluate ⁶⁸Ga-PET/CT quantification variability in a multicentre setting. Methods A survey across Dutch hospitals was performed to evaluate differences in clinical ⁶⁸Ga PET/CT study protocols. ⁶⁸Ga and ¹⁸F phantom acquisitions were performed by 8 centres with 13 different PET/CT systems according to EARL protocol. The cylindrical phantom and NEMA image quality (IQ) phantom were used to assess image noise and to identify recovery coefficients (RCs) for quantitative analysis. Both phantoms were used to evaluate cross-calibration between the PET/CT system and local dose calibrator. Results The survey across Dutch hospitals showed a large variation in clinical ⁶⁸Ga PET/CT acquisition and reconstruction protocols. ⁶⁸Ga PET/CT image noise was below 10%. Cross-calibration was within 10% deviation, except for one system to overestimate ¹⁸F and two systems to underestimate the ⁶⁸Ga activity concentration. RC-curves for ¹⁸F and ⁶⁸Ga were within and on the lower limit of current EARL standards, respectively. After correction for local ⁶⁸Ga/¹⁸F cross-calibration, mean ⁶⁸Ga performance was 5% below mean EARL performance specifications. Conclusions ⁶⁸Ga PET/CT quantification performs on the lower limits of the current EARL RC standards for ¹⁸F. Correction for local ⁶⁸Ga/¹⁸F cross-calibration mismatch is advised, while maintaining the EARL reconstruction protocol thereby avoiding multiple EARL protocols.