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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 10(63), 2019

DOI: 10.1128/aac.01078-19

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Antimicrobial Activity of Exebacase (Lysin CF-301) against the Most Common Causes of Infective Endocarditis

Journal article published in 2019 by Aubrey Watson, Jun Taek Oh, Karen Sauve, Patricia A. Bradford ORCID, Cara Cassino, Raymond Schuch ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Exebacase, a recombinantly produced lysin (cell wall hydrolase), and comparator antibiotics were tested by the broth microdilution method against strain sets of Staphylococcus and Streptococcus spp., which are the most common causes of infective endocarditis in humans. Exebacase was active against all Staphylococcus spp. tested, including S. aureus and coagulase-negative staphylococci (MIC 50/90 , 0.5/1 μg/ml). Activity against Streptococcus spp.