Published in

Springer Nature [academic journals on nature.com], Molecular Psychiatry, 4(14), p. 376-380, 2008

DOI: 10.1038/mp.2008.144

Links

Tools

Export citation

Search in Google Scholar

Singleton Deletions Throughout the Genome Increase Risk of Bipolar Disorder

Journal article published in 2008 by Dandan Zhang, Lijun Cheng, Yudong Qian, Ney Alliey-Rodriguez, John R. Kelsoe, Tiffany Greenwood, Caroline Nievergelt ORCID, Thomas B. Barrett, Rebecca McKinney, Nicholas Schork, Erin N. Smith, Cinnamon Bloss, John Nurnberger, Howard J. Edenberg ORCID, Tatiana Foroud and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genome-wide copy number variant (CNV) survey of 1001 cases and 1034 controls using the Affymetrix single nucleotide polymorphism (SNP) 6.0 SNP and CNV platform. Singleton deletions (deletions that appear only once in the dataset) more than 100 kb in length are present in 16.2% of BD cases in contrast to 12.3% of controls (permutation P=0.007). This effect was more pronounced for age at onset of mania <or=18 years old. Our results strongly suggest that BD can result from the effects of multiple rare structural variants.