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SAGE Publications, Evolutionary Bioinformatics, (10), p. EBO.S13759, 2014

DOI: 10.4137/ebo.s13759

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The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite

Journal article published in 2014 by Diogo A. Tschoeke, Leandro de Mattos Pereira, Herbert Leonel de Matos Guedes, Antonio Basilio de Miranda, Gisele L. Nunes, Rodrigo Jardim ORCID, Joana Lima, Aline S. R. Dumaresq, Monete R. Gomes, Daniel R. Loureiro, Patricia H. Stoco, Alberto M. R. Davila, Herbert Leonel De Matos Gliedes, Jeronimo Ruiz, André Pitaluga and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis using six Leishmania species showed a core set of 7,016 orthologs. L. amazonensis and Leishmania mexicana share the largest number of distinct orthologs, while Leishmania braziliensis presented the largest number of inparalogs. Additionally, phylogenomic analysis confirmed the taxonomic position for L. amazonensis within the “Mexicana complex”, reinforcing understanding of the split of New and Old World Leishmania. Potential non-homologous isofunctional enzymes (NISE) were identified between L. amazonensis and Homo sapiens that could provide new drug targets for development.