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Oxford University Press, The American Journal of Clinical Nutrition, 6(97), p. 1395-1402, 2013

DOI: 10.3945/ajcn.112.052183

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Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

Journal article published in 2013 by Toshiko Tanaka, Julius S. Ngwa, Frank Ja A. van Rooij ORCID, M. Carola Zillikens, Mary K. Wojczynski, Alexis C. Frazier-Wood ORCID, Denise K. Houston, Stavroula Kanoni, Rozenn N. Lemaitre, Jian'an Luan, Vera Mikkila, Frida Renström, Emily Sonestedt, Jing Hua Zhao, Audrey Y. Chu and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants. Objective: The objective of the study was to identify common genetic variants that are associated with macronutrient intake. Design: We performed 2-stage genome-wide association (GWA) meta-analysis of macronutrient intake in populations of European descent. Macronutrients were assessed by using food-frequency questionnaires and analyzed as percentages of total energy consumption from total fat, protein, and carbohydrate. From the discovery GWA (n = 38,360), 35 independent loci associated with macronutrient intake at P