Published in

Future Medicine, Nanomedicine, 1(9), p. 135-151, 2014

DOI: 10.2217/nnm.13.194

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Surface modification of nonviral nanocarriers for enhanced gene delivery

Journal article published in 2014 by Charles Fortier, Yves Durocher, Gregory De Crescenzo
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Biomedical nanotechnology has given a new lease of life to gene therapy with the ever-developing and ever-diversifying nonviral gene delivery nanocarriers. These are designed to pass a series of barriers in order to bring their nucleic acid cargo to the right subcellular location of particular cells. For a given application, each barrier has its dedicated strategy, which translates into a physicochemical, biological and temporal identity of the nanocarrier surface. Different strategies have thus been explored to implement adequate surface identities on nanocarriers over time for systemic delivery. In that context, this review will mainly focus on organic nanocarriers, for which these strategies will be described and discussed. ; peer reviewed: yes ; system details: This record was machine loaded using metadata from Scopus ; NRC Pub: yes