Genetic loci influencing kidney function and chronic kidney disease.

van der Heide, Jj; Lord, Gm; Zhang, Weihua; van der Harst, Pim; Lawlor, Debbie A.; Sehmi, Js; Gale, Dp; Wass, Mn; Smith, Gd; Terence Cook, H.; Ht, Cook; Dikkeschei, Ld; Forouhi, Ng; Beckmann, Jacqui; Gansevoort, Rt; Bochud, Murielle; Hepkema, Bg; Homan van der Heide, Jaap Jj; Cook, Ht Terence; de Silva, Ranil; de Jong, Pe; Cotlarciuc, Ioana; Devuyst, Olivier; Deng, Guohong; Dimkovic, Nada; Dockrell, Mark; Dominiczak, Anna; Ebrahim, Shah; Loos, Rj; Eggermann, Thomas; Farrall, Martin; Ferrucci, Luigi; Mar?chal, C.; Floege, Jurgen; Munroe, Pb; Penninx, Bw; Han, Xijin; Hedblad, Bo; Hernandez-Fuentes, Maria; Roderick, Pj; Hypponen, Elina; Nj, Samani; Johnson, Toby; Kleefstra, Nanne; Lagou, Vasiliki; Lapsley, Marta; Ma, Seelen; Li, Yun; Luan, Jian'an; Sj?gren, M.; Luttropp, Karin; Maréchal, Celine; Melander, Olle; Smit, Jh; Nordfors, Louise; Parsa, Afshin; Spector, Td; Peltonen, Leena; Sternberg, Mj; Perucha, Esperanza; Pouta, Anneli; Prokopenko, Inga; Lj, Ubink Veltmaat; Ruokonen, Aimo; Samani, Nilesh J.; Sanna, Serena; Ubink-Veltmaat, Lj; Schalling, Martin; Schlessinger, David; Schlieper, Georg; Wareham, Nj; Seelen, Marc A. J.; Shuldiner, Alan R.; Maxwell, Ph; Sjögren, Marketa; McCarthy, Mi; Snieder, Harold; Jarvelin, Mr; Soranzo, Nicole; Stenvinkel, Peter; Js, Kooner; Swaminathan, Ramasamyiyer; Tanaka, Toshiko; Chambers, Jc; Uda, Manuela; Vollenweider, Peter; Da, Lawlor; Wallace, Chris; Ahmadi, Kr; Waterworth, Dawn; Zerres, Klaus; Waeber, Gerard; Bakker, Sj; Bilo, Hj; Brown, Mj; Caulfield, Mj; Mooser, Vincent; Connell, Jm; Lightstone, Liz; Davey Smith, G.; Scott, James; Navis, Gerjan; Elliott, Paul; Ar, Shuldiner; Kooner, Jaspal S.; Abecasis, Gr

Dissemin
Graham Lord
van der Heide et al., 2010

Tools

Export citation

Format

@article{van der Heide2010,
  abstract = {Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease. ; 20774},
  author = {van der Heide, Jj and Lord, Gm and Zhang, Weihua and van der Harst, Pim and Lawlor, Debbie A. and Sehmi, Js and Gale, Dp and Wass, Mn and Smith, Gd and Terence Cook, H. and Ht, Cook and Dikkeschei, Ld and Forouhi, Ng and Beckmann, Jacqui and Gansevoort, Rt and Bochud, Murielle and Hepkema, Bg and Homan van der Heide, Jaap Jj and Cook, Ht Terence and de Silva, Ranil and de Jong, Pe and Cotlarciuc, Ioana and Devuyst, Olivier and Deng, Guohong and Dimkovic, Nada and Dockrell, Mark and Dominiczak, Anna and Ebrahim, Shah and Loos, Rj and Eggermann, Thomas and Farrall, Martin and Ferrucci, Luigi and Mar?chal, C. and Floege, Jurgen and Munroe, Pb and Penninx, Bw and Han, Xijin and Hedblad, Bo and Hernandez-Fuentes, Maria and Roderick, Pj and Hypponen, Elina and Nj, Samani and Johnson, Toby and Kleefstra, Nanne and Lagou, Vasiliki and Lapsley, Marta and Ma, Seelen and Li, Yun and Luan, Jian'an and Sj?gren, M. and Luttropp, Karin and Maréchal, Celine and Melander, Olle and Smit, Jh and Nordfors, Louise and Parsa, Afshin and Spector, Td and Peltonen, Leena and Sternberg, Mj and Perucha, Esperanza and Pouta, Anneli and Prokopenko, Inga and Lj, Ubink Veltmaat and Ruokonen, Aimo and Samani, Nilesh J. and Sanna, Serena and Ubink-Veltmaat, Lj and Schalling, Martin and Schlessinger, David and Schlieper, Georg and Wareham, Nj and Seelen, Marc A. J. and Shuldiner, Alan R. and Maxwell, Ph and Sjögren, Marketa and McCarthy, Mi and Snieder, Harold and Jarvelin, Mr and Soranzo, Nicole and Stenvinkel, Peter and Js, Kooner and Swaminathan, Ramasamyiyer and Tanaka, Toshiko and Chambers, Jc and Uda, Manuela and Vollenweider, Peter and Da, Lawlor and Wallace, Chris and Ahmadi, Kr and Waterworth, Dawn and Zerres, Klaus and Waeber, Gerard and Bakker, Sj and Bilo, Hj and Brown, Mj and Caulfield, Mj and Mooser, Vincent and Connell, Jm and Lightstone, Liz and Davey Smith, G. and Scott, James and Navis, Gerjan and Elliott, Paul and Ar, Shuldiner and Kooner, Jaspal S. and Abecasis, Gr},
  doi = {10.1038/ng.566},
  month = {jan},
  title = {Genetic loci influencing kidney function and chronic kidney disease.},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/20383145},
  year = {2010}
}

Download

Export citation

Search in Google Scholar

Genetic loci influencing kidney function and chronic kidney disease.

Journal article published in 2010 by Jj van der Heide, Gm Lord

, Weihua Zhang, Pim van der Harst, Debbie A. Lawlor, Js Sehmi, Dp Gale

, Mn Wass, Gd Smith, H. Terence Cook, Cook Ht, Ld Dikkeschei, Ng Forouhi, Jacqui Beckmann

, Rt Gansevoort and other authors. Jj van der Heide, Gm Lord

, Weihua Zhang, Pim van der Harst, Debbie A. Lawlor, Js Sehmi, Dp Gale

, Mn Wass, Gd Smith, H. Terence Cook, Cook Ht, Ld Dikkeschei, Ng Forouhi, Jacqui Beckmann

, Rt Gansevoort, Murielle Bochud, Bg Hepkema, Jaap Jj Homan van der Heide, Ht Terence Cook, Ranil de Silva, Pe de Jong, Ioana Cotlarciuc, Olivier Devuyst, Guohong Deng

, Nada Dimkovic, Mark Dockrell, Anna Dominiczak, Shah Ebrahim, Rj Loos, Thomas Eggermann, Martin Farrall, Luigi Ferrucci, C. Mar?chal, Jurgen Floege, Pb Munroe, Bw Penninx, Xijin Han, Bo Hedblad, Maria Hernandez-Fuentes, Pj Roderick, Elina Hypponen

, Samani Nj, Toby Johnson

, Nanne Kleefstra, Vasiliki Lagou, Marta Lapsley, Seelen Ma, Yun Li, Jian'an Luan, M. Sj?gren, Karin Luttropp, Celine Maréchal, Olle Melander, Jh Smit, Louise Nordfors, Afshin Parsa, Td Spector, Leena Peltonen, Mj Sternberg, Esperanza Perucha

, Anneli Pouta, Inga Prokopenko

, Ubink Veltmaat Lj, Aimo Ruokonen, Nilesh J. Samani, Serena Sanna

, Lj Ubink-Veltmaat, Martin Schalling, David Schlessinger, Georg Schlieper, Nj Wareham, Marc A. J. Seelen, Alan R. Shuldiner, Ph Maxwell, Marketa Sjögren, Mi McCarthy, Harold Snieder, Mr Jarvelin, Nicole Soranzo, Peter Stenvinkel, Kooner Js, Ramasamyiyer Swaminathan, Toshiko Tanaka, Jc Chambers, Manuela Uda, Peter Vollenweider, Lawlor Da, Chris Wallace, Kr Ahmadi, Dawn Waterworth, Klaus Zerres, Gerard Waeber, Sj Bakker, Hj Bilo, Mj Brown, Mj Caulfield, Vincent Mooser, Jm Connell, Liz Lightstone, G. Davey Smith, James Scott, Gerjan Navis, Paul Elliott, Shuldiner Ar, Jaspal S. Kooner, Gr Abecasis

Show less

This paper is available in a repository.

Full text: Download

Preprint: policy unknown

Upload

Postprint: policy unknown

Upload

Published version: policy unknown

Upload

Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease. ; 20774

Links

Tools

Genetic loci influencing kidney function and chronic kidney disease.

Abstract