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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(56), p. 4018-4020, 2012

DOI: 10.1128/aac.06474-11

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Etravirine Concentrations in the Cervicovaginal Compartment in HIV-1-Infected Women Receiving Etravirine-Containing Antiretroviral Therapy: DIVA 02 Study

Journal article published in 2012 by C. Clavel, G. Peytavin, R. Tubiana, C. Soulié, E. Courbon, C. Crenn-Hebert, H. Ichou, C. Blanc, L. Schneider, C. Katlama, A.-G. Marcelin ORCID, L. Mandelbrot
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We studied the penetration of etravirine and HIV shedding in the genital tract among 12 HIV-1-infected women receiving an etravirine-containing regimen who had <40 copies/ml blood plasma (BP) HIV RNA. None of the cervicovaginal fluid (CVF) samples showed detectable HIV RNA. Median etravirine concentrations were 663 ng/ml in BP and 857 ng/ml in CVF, with a CVF/BP etravirine ratio of approximately 1.2. This good penetration of etravirine may contribute to the control of viral replication in the female genital tract.