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Nature Research, Nature Communications, 1(10), 2019

DOI: 10.1038/s41467-019-12671-y

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Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2

Journal article published in 2019 by Mark A. Corbett ORCID, Thessa Kroes, Liana Veneziano ORCID, Mark F. Bennett ORCID, Rahel Florian, Amy L. Schneider ORCID, Antonietta Coppola, Laura Licchetta, Silvana Franceschetti, Antonio Suppa ORCID, Aaron Wenger, Davide Mei ORCID, Manuela Pendziwiat, Sabine Kaya, Massimo Delledonne ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractFamilial Adult Myoclonic Epilepsy (FAME) is characterised by cortical myoclonic tremor usually from the second decade of life and overt myoclonic or generalised tonic-clonic seizures. Four independent loci have been implicated in FAME on chromosomes (chr) 2, 3, 5 and 8. Using whole genome sequencing and repeat primed PCR, we provide evidence that chr2-linked FAME (FAME2) is caused by an expansion of an ATTTC pentamer within the first intron of STARD7. The ATTTC expansions segregate in 158/158 individuals typically affected by FAME from 22 pedigrees including 16 previously reported families recruited worldwide. RNA sequencing from patient derived fibroblasts shows no accumulation of the AUUUU or AUUUC repeat sequences and STARD7 gene expression is not affected. These data, in combination with other genes bearing similar mutations that have been implicated in FAME, suggest ATTTC expansions may cause this disorder, irrespective of the genomic locus involved.