Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Mavaddat, Nasim; Michailidou, Kyriaki; Dennis, Joe; Lush, Michael; Fachal, Laura; Tyrer, Jonathan P.; Lee, Andrew; Chen, Ting-Huei; Wang, Qin; Bolla, Manjeet K.; Yang, Xin; Adank, Muriel A.; Ahearn, Thomas; Aittomäki, Kristiina; Allen, Jamie; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Auer, Paul L.; Auvinen, Päivi; Barrdahl, Myrto; Beane Freeman, Laura E.; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bernstein, Leslie; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Stig E.; Bonanni, Bernardo; Børresen-Dale, Anne-Lise; Brauch, Hiltrud; Bremer, Michael; Brenner, Hermann; Brentnall, Adam; Brock, Ian W.; Brooks-Wilson, Angela; Brucker, Sara Y.; Brüning, Thomas; Burwinkel, Barbara; Campa, Daniele; Carter, Brian D.; Castelao, Jose E.; Chanock, Stephen J.; Chlebowski, Rowan; Christiansen, Hans; Clarke, Christine L.; Collée, J. Margriet; Cordina-Duverger, Emilie; Cornelissen, Sten; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Daly, Mary B.; Devilee, Peter; Dörk, Thilo; dos-Santos-Silva, Isabel; Dumont, Martine; Durcan, Lorraine; Dwek, Miriam; Eccles, Diana M.; Ekici, Arif B.; Eliassen, A. Heather; Ellberg, Carolina; Engel, Christoph; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine; Fletcher, Olivia; Flyger, Henrik; Försti, Asta; Fritschi, Lin; Gabrielson, Marike; Gago-Dominguez, Manuela; Gapstur, Susan M.; García-Sáenz, José A.; Gaudet, Mia M.; Georgoulias, Vassilios; Giles, Graham G.; Gilyazova, Irina R.; Glendon, Gord; Goldberg, Mark S.; Goldgar, David E.; González-Neira, Anna; Grenaker Alnæs, Grethe I.; Grip, Mervi; Gronwald, Jacek; Grundy, Anne; Guénel, Pascal; Haeberle, Lothar; Hahnen, Eric; Haiman, Christopher A.; Håkansson, Niclas; Hamann, Ute; Hankinson, Susan E.; Harkness, Elaine F.; Hart, Steven N.; He, Wei; Hein, Alexander; Heyworth, Jane; Hillemanns, Peter; Hollestelle, Antoinette; Hooning, Maartje J.; Hoover, Robert N.; Hopper, John L.; Howell, Anthony; Huang, Guanmengqian; Humphreys, Keith; Hunter, David J.; Jakimovska, Milena; Jakubowska, Anna; Janni, Wolfgang; John, Esther M.; Johnson, Nichola; Jones, Michael E.; Jukkola-Vuorinen, Arja; Jung, Audrey; Kaaks, Rudolf; Kaczmarek, Katarzyna; Kataja, Vesa; Keeman, Renske; Kerin, Michael J.; Khusnutdinova, Elza; Kiiski, Johanna I.; Knight, Julia A.; Ko, Yon-Dschun; Kosma, Veli-Matti; Lee, Eunjung; Koutros, Stella; Lejbkowicz, Flavio; Lilyquist, Jenna; Kristensen, Vessela N.; Krüger, Ute; Lindblom, Annika; Kühl, Tabea; Lindström, Sara; Lambrechts, Diether; Lissowska, Jolanta; Lo, Wing-Yee; Le Marchand, Loic; Loibl, Sibylle; Long, Jirong; Lubiński, Jan; Lux, Michael P.; MacInnis, Robert J.; Maishman, Tom; Makalic, Enes; Maleva Kostovska, Ivana; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Martens, John W. M.; Martinez, Maria Elena; Mavroudis, Dimitrios; McLean, Catriona; Meindl, Alfons; Menon, Usha; Middha, Pooja; Miller, Nicola; Moreno, Fernando; Mulligan, Anna Marie; Mulot, Claire; Muñoz-Garzon, Victor M.; Neuhausen, Susan L.; Nevanlinna, Heli; Neven, Patrick; Newman, William G.; Nielsen, Sune F.; Nordestgaard, Børge G.; Norman, Aaron; Offit, Kenneth; Olson, Janet E.; Olsson, Håkan; Orr, Nick; Pankratz, V. Shane; Park-Simon, Tjoung-Won; Perez, Jose I. A.; Pérez-Barrios, Clara; Peterlongo, Paolo; Peto, Julian; Pinchev, Mila; Plaseska-Karanfilska, Dijana; Polley, Eric C.; Prentice, Ross; Presneau, Nadege; Prokofyeva, Darya; Purrington, Kristen; Pylkäs, Katri; Rack, Brigitte; Radice, Paolo; Rau-Murthy, Rohini; Rennert, Gad; Rennert, Hedy S.; Rhenius, Valerie; Robson, Mark; Romero, Atocha; Ruddy, Kathryn J.; Ruebner, Matthias; Saloustros, Emmanouil; Sandler, Dale P.; Sawyer, Elinor J.; Schmidt, Daniel F.; Schmutzler, Rita K.; Schneeweiss, Andreas; Schoemaker, Minouk J.; Schumacher, Fredrick; Schürmann, Peter; Schwentner, Lukas; Scott, Christopher; Scott, Rodney J.; Seynaeve, Caroline; Shah, Mitul; Sherman, Mark E.; Shrubsole, Martha J.; Shu, Xiao-Ou; Slager, Susan; Smeets, Ann; Sohn, Christof; Soucy, Penny; Southey, Melissa C.; Spinelli, John J.; Stegmaier, Christa; Stone, Jennifer; Swerdlow, Anthony J.; Tamimi, Rulla M.; Tapper, William J.; Taylor, Jack A.; Terry, Mary Beth; Thöne, Kathrin; Tollenaar, Rob A. E. M.; Tomlinson, Ian; Truong, Thérèse; Tzardi, Maria; Ulmer, Hans-Ulrich; Untch, Michael; Vachon, Celine M.; van Veen, Elke M.; Vijai, Joseph; Weinberg, Clarice R.; Wendt, Camilla; Whittemore, Alice S.; Wildiers, Hans; Willett, Walter; Winqvist, Robert; Wolk, Alicja; Yang, Xiaohong R.; Yannoukakos, Drakoulis; Zhang, Yan; Zheng, Wei; Ziogas, Argyrios; Dunning, Alison M.; Thompson, Deborah J.; Chenevix-Trench, Georgia; Chang-Claude, Jenny; Schmidt, Marjanka K.; Hall, Per; Milne, Roger L.; Pharoah, Paul D. P.; Antoniou, Antonis C.; Chatterjee, Nilanjan; Kraft, Peter; García-Closas, Montserrat; Simard, Jacques; Easton, Douglas F.

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Andrew Lee
Mavaddat et al., 2018

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Cell Press, American Journal of Human Genetics, 1(104), p. 21-34, 2019

DOI: 10.1016/j.ajhg.2018.11.002

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@article{Mavaddat2018,
  author = {Mavaddat, Nasim and Michailidou, Kyriaki and Dennis, Joe and Lush, Michael and Fachal, Laura and Tyrer, Jonathan P. and Lee, Andrew and Chen, Ting-Huei and Wang, Qin and Bolla, Manjeet K. and Yang, Xin and Adank, Muriel A. and Ahearn, Thomas and Aittomäki, Kristiina and Allen, Jamie and Andrulis, Irene L. and Anton-Culver, Hoda and Antonenkova, Natalia N. and Arndt, Volker and Aronson, Kristan J. and Auer, Paul L. and Auvinen, Päivi and Barrdahl, Myrto and Beane Freeman, Laura E. and Beckmann, Matthias W. and Behrens, Sabine and Benitez, Javier and Bermisheva, Marina and Bernstein, Leslie and Blomqvist, Carl and Bogdanova, Natalia V. and Bojesen, Stig E. and Bonanni, Bernardo and Børresen-Dale, Anne-Lise and Brauch, Hiltrud and Bremer, Michael and Brenner, Hermann and Brentnall, Adam and Brock, Ian W. and Brooks-Wilson, Angela and Brucker, Sara Y. and Brüning, Thomas and Burwinkel, Barbara and Campa, Daniele and Carter, Brian D. and Castelao, Jose E. and Chanock, Stephen J. and Chlebowski, Rowan and Christiansen, Hans and Clarke, Christine L. and Collée, J. Margriet and Cordina-Duverger, Emilie and Cornelissen, Sten and Couch, Fergus J. and Cox, Angela and Cross, Simon S. and Czene, Kamila and Daly, Mary B. and Devilee, Peter and Dörk, Thilo and dos-Santos-Silva, Isabel and Dumont, Martine and Durcan, Lorraine and Dwek, Miriam and Eccles, Diana M. and Ekici, Arif B. and Eliassen, A. Heather and Ellberg, Carolina and Engel, Christoph and Eriksson, Mikael and Evans, D. Gareth and Fasching, Peter A. and Figueroa, Jonine and Fletcher, Olivia and Flyger, Henrik and Försti, Asta and Fritschi, Lin and Gabrielson, Marike and Gago-Dominguez, Manuela and Gapstur, Susan M. and García-Sáenz, José A. and Gaudet, Mia M. and Georgoulias, Vassilios and Giles, Graham G. and Gilyazova, Irina R. and Glendon, Gord and Goldberg, Mark S. and Goldgar, David E. and González-Neira, Anna and Grenaker Alnæs, Grethe I. and Grip, Mervi and Gronwald, Jacek and Grundy, Anne and Guénel, Pascal and Haeberle, Lothar and Hahnen, Eric and Haiman, Christopher A. and Håkansson, Niclas and Hamann, Ute and Hankinson, Susan E. and Harkness, Elaine F. and Hart, Steven N. and He, Wei and Hein, Alexander and Heyworth, Jane and Hillemanns, Peter and Hollestelle, Antoinette and Hooning, Maartje J. and Hoover, Robert N. and Hopper, John L. and Howell, Anthony and Huang, Guanmengqian and Humphreys, Keith and Hunter, David J. and Jakimovska, Milena and Jakubowska, Anna and Janni, Wolfgang and John, Esther M. and Johnson, Nichola and Jones, Michael E. and Jukkola-Vuorinen, Arja and Jung, Audrey and Kaaks, Rudolf and Kaczmarek, Katarzyna and Kataja, Vesa and Keeman, Renske and Kerin, Michael J. and Khusnutdinova, Elza and Kiiski, Johanna I. and Knight, Julia A. and Ko, Yon-Dschun and Kosma, Veli-Matti and Lee, Eunjung and Koutros, Stella and Lejbkowicz, Flavio and Lilyquist, Jenna and Kristensen, Vessela N. and Krüger, Ute and Lindblom, Annika and Kühl, Tabea and Lindström, Sara and Lambrechts, Diether and Lissowska, Jolanta and Lo, Wing-Yee and Le Marchand, Loic and Loibl, Sibylle and Long, Jirong and Lubiński, Jan and Lux, Michael P. and MacInnis, Robert J. and Maishman, Tom and Makalic, Enes and Maleva Kostovska, Ivana and Mannermaa, Arto and Manoukian, Siranoush and Margolin, Sara and Martens, John W. M. and Martinez, Maria Elena and Mavroudis, Dimitrios and McLean, Catriona and Meindl, Alfons and Menon, Usha and Middha, Pooja and Miller, Nicola and Moreno, Fernando and Mulligan, Anna Marie and Mulot, Claire and Muñoz-Garzon, Victor M. and Neuhausen, Susan L. and Nevanlinna, Heli and Neven, Patrick and Newman, William G. and Nielsen, Sune F. and Nordestgaard, Børge G. and Norman, Aaron and Offit, Kenneth and Olson, Janet E. and Olsson, Håkan and Orr, Nick and Pankratz, V. Shane and Park-Simon, Tjoung-Won and Perez, Jose I. A. and Pérez-Barrios, Clara and Peterlongo, Paolo and Peto, Julian and Pinchev, Mila and Plaseska-Karanfilska, Dijana and Polley, Eric C. and Prentice, Ross and Presneau, Nadege and Prokofyeva, Darya and Purrington, Kristen and Pylkäs, Katri and Rack, Brigitte and Radice, Paolo and Rau-Murthy, Rohini and Rennert, Gad and Rennert, Hedy S. and Rhenius, Valerie and Robson, Mark and Romero, Atocha and Ruddy, Kathryn J. and Ruebner, Matthias and Saloustros, Emmanouil and Sandler, Dale P. and Sawyer, Elinor J. and Schmidt, Daniel F. and Schmutzler, Rita K. and Schneeweiss, Andreas and Schoemaker, Minouk J. and Schumacher, Fredrick and Schürmann, Peter and Schwentner, Lukas and Scott, Christopher and Scott, Rodney J. and Seynaeve, Caroline and Shah, Mitul and Sherman, Mark E. and Shrubsole, Martha J. and Shu, Xiao-Ou and Slager, Susan and Smeets, Ann and Sohn, Christof and Soucy, Penny and Southey, Melissa C. and Spinelli, John J. and Stegmaier, Christa and Stone, Jennifer and Swerdlow, Anthony J. and Tamimi, Rulla M. and Tapper, William J. and Taylor, Jack A. and Terry, Mary Beth and Thöne, Kathrin and Tollenaar, Rob A. E. M. and Tomlinson, Ian and Truong, Thérèse and Tzardi, Maria and Ulmer, Hans-Ulrich and Untch, Michael and Vachon, Celine M. and van Veen, Elke M. and Vijai, Joseph and Weinberg, Clarice R. and Wendt, Camilla and Whittemore, Alice S. and Wildiers, Hans and Willett, Walter and Winqvist, Robert and Wolk, Alicja and Yang, Xiaohong R. and Yannoukakos, Drakoulis and Zhang, Yan and Zheng, Wei and Ziogas, Argyrios and Dunning, Alison M. and Thompson, Deborah J. and Chenevix-Trench, Georgia and Chang-Claude, Jenny and Schmidt, Marjanka K. and Hall, Per and Milne, Roger L. and Pharoah, Paul D. P. and Antoniou, Antonis C. and Chatterjee, Nilanjan and Kraft, Peter and García-Closas, Montserrat and Simard, Jacques and Easton, Douglas F.},
  doi = {10.1016/j.ajhg.2018.11.002},
  journal = {American Journal of Human Genetics},
  month = {dec},
  pages = {21-34},
  title = {Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes},
  url = {https://oadoi.org/10.1016/j.ajhg.2018.11.002},
  volume = {104},
  year = {2018}
}

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