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Cold Spring Harbor Laboratory Press, Genes & Development, 2(21), p. 143-147, 2007

DOI: 10.1101/gad.414807

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The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse

Journal article published in 2007 by Hermann Bauer, Nathalie Véron, Jürgen Willert, Bernhard G. Herrmann
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Transmission ratio distortion (TRD), the preferential inheritance of the t haplotype from t/+ males, is caused by the cooperative effect of four t-complex distorters (Tcd1–4) and the single t-complex responder (Tcr) on sperm motility. Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region. The t allele of Fgd2 is overexpressed in testis compared with wild type. A loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio of the t haplotype th49, directly demonstrating the role of Fgd2 as Distorter. Fgd2 identifies a second Rho G protein signaling pathway promoting TRD.