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Impact Journals, Oncotarget, 7(6), p. 5354-5368, 2015

DOI: 10.18632/oncotarget.3022

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Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells

Journal article published in 2015 by Sebastian Drube, Franziska Weber, Romy Loschinski, Mandy Rothe, Anja Rabenhorst, Christiane Göpfert, Mandy Beyer, Isabel Meininger, Michaela A. Diamanti, David Stegner, Norman Häfner, Kirstin Reinecke, Thomas Herdegen, Martin Böttcher ORCID, Florian R. Greten and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Mast cell differentiation and proliferation depends on IL-3. IL-3 induces the activation of MAP-kinases and STATs and consequently induces proliferation and survival. Dysregulation of IL-3 signaling pathways also contribute to inflammation and tumorigenesis. We show here that IL-3 induces a SFK- and Ca2+-dependent activation of the inhibitor of κB kinases 2 (IKK2) which results in mast cell proliferation and survival but does not induce IκBα-degradation and NFκB activation. Therefore we propose the term “subthreshold IKK activation”.