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Oxford University Press (OUP), Journals of Gerontology, Series A, 11(67), p. 1153-1160

DOI: 10.1093/gerona/gls103

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Distinguishing Between Longevity and Buffered-Deleterious Genotypes for Exceptional Human Longevity: The Case of the MTP Gene

Journal article published in 2012 by Derek M. Huffman, Joris Deelen ORCID, Kenny Ye ORCID, Aviv Bergman, Eline P. Slagboom ORCID, Nir Barzilai, Gil Atzmon
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The single nucleotide polymorphism, rs2866164, in the MTP gene, has been associated with human longevity but has not been validated by subsequent longevity studies. Using our population of Ashkenazi Jews, we find that the MTP CC genotype is significantly overrepresented in centenarians and their offspring, as compared with controls (p