Published in
American Society of Hematology, Blood, 11(132), p. 1180-1192, 2018
DOI: 10.1182/blood-2018-02-831503
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AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation
Journal article published in 2018 by
Sophie Lepropre,
Shakeel Kautbally,
Marie Octave,
Audrey Ginion,
Marie-Blanche Onselaer,
Gregory R. Steinberg,
Bruce E. Kemp 
,
Alexandre Hego,
Odile Wéra,
Sanne Brouns,
Frauke Swieringa,
Martin Giera ,
Victor M. Darley-Usmar,
Jérôme Ambroise,
Bruno Guigas
and other authors.
,
Alexandre Hego,
Odile Wéra,
Sanne Brouns,
Frauke Swieringa,
Martin Giera ,
Victor M. Darley-Usmar,
Jérôme Ambroise,
Bruno Guigas
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key PointsAMPK-ACC signaling in platelets is a key mechanism regulating primary hemostasis and arterial thrombosis. AMPK-ACC signaling controls collagen-induced TXA2 generation and dense granule release by modulating platelet phospholipid content.