Published in
American Society of Hematology, Blood, 8(129), p. 959-969
DOI: 10.1182/blood-2016-04-709584
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A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production
Journal article published in 2017 by
Hua Yu 
,
Chiara Borsotti,
Jean-Nicolas Schickel,
Shu Zhu,
Till Strowig,
Elizabeth E. Eynon,
Davor Frleta,
Cagan Gurer,
Andrew J. Murphy,
George D. Yancopoulos,
Eric Meffre,
Markus G. Manz ,
Richard A. Flavell
,
Chiara Borsotti,
Jean-Nicolas Schickel,
Shu Zhu,
Till Strowig,
Elizabeth E. Eynon,
Davor Frleta,
Cagan Gurer,
Andrew J. Murphy,
George D. Yancopoulos,
Eric Meffre,
Markus G. Manz ,
Richard A. Flavell
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
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Abstract
Key Points Human IL-6 improves T-cell engraftment and serum IgG production in humanized mice. IgG-switched memory B cells in IL-6 knock-in mice displayed a diverse antibody repertoire and high specificity against immunized antigen.