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Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome
Journal article published in 2014 by
Tomofumi Misaka 
,
Satoshi Suzuki,
Nobuo Sakamoto,
Takayoshi Yamaki,
Koichi Sugimoto ,
Hiroyuki Kunii,
Kazuhiko Nakazato,
Shu-Ichi Saitoh,
Tatsuya Sawamura,
Toshiyuki Ishibashi,
Yasuchika Takeishi
,
Satoshi Suzuki,
Nobuo Sakamoto,
Takayoshi Yamaki,
Koichi Sugimoto ,
Hiroyuki Kunii,
Kazuhiko Nakazato,
Shu-Ichi Saitoh,
Tatsuya Sawamura,
Toshiyuki Ishibashi,
Yasuchika Takeishi
Abstract
Background. Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined. Methods. Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI. Results. We found positive correlations between soluble LOX-1 levels in the Ao and CS in both ACS and EAP patients (P